ArticleBrain structure & function2017
The integrity of the nucleus of the lateral olfactory tract is essential for the normal functioning of the olfactory system.
Article in Brain structure & function, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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16 citing papers in PubMed, 22 citations in OpenAlex.
- Brain-wide activity mapping reveals the somatosensory cortex as a sex-specific regulator of hedonic feeding.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026Article
- Effects of electroacupuncture at Zusanli on pain-perception-related brain nuclei in KOA mice: a study on cortical and subcortical c-fos expression.Behavioral and brain functions : BBF · 2026Article
- Collateralization patterns of principal basolateral amygdala neurons delineate distinct output streams.iScience · 2025Article
- Synaptic Connectivity and Electrophysiological Properties of the Nucleus of the Lateral Olfactory Tract.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- The olfactory striae: A historical perspective on the inconsistent anatomy of the bulbar projections.Journal of anatomy · 2024Review
- Olfactory deficits in aging and Alzheimer's-spotlight on inhibitory interneurons.Frontiers in neuroscience · 2024Review
- Nucleus of the lateral olfactory tract: A hub linking the water homeostasis-associated supraoptic nucleus-arginine vasopressin circuit and neocortical regions to promote social behavior under osmotic challenge.Journal of neuroendocrinology · 2023Article
- Melanocortin 4 receptor signaling in Sim1 neurons permits sexual receptivity in female mice.Frontiers in endocrinology · 2023Article
- Neural and Hormonal Basis of Opposite-Sex Preference by Chemosensory Signals.International journal of molecular sciences · 2021Review
- Understanding Emotions: Origins and Roles of the Amygdala.Biomolecules · 2021Review
- Bi-directional encoding of context-based odors and behavioral states by the nucleus of the lateral olfactory tract.iScience · 2021Article
- Expression of FLRT2 in Postnatal Central Nervous System Development and After Spinal Cord Injury.Frontiers in molecular neuroscience · 2021Article
- Assessment of direct knowledge of the human olfactory system.Experimental neurology · 2020Review
- The Zebrafish Amygdaloid Complex - Functional Ground Plan, Molecular Delineation, and Everted Topology.Frontiers in neuroscience · 2020Article
- A whole-brain atlas of monosynaptic input targeting four different cell types in the medial prefrontal cortex of the mouse.Nature neuroscience · 2019Article
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The nucleus of the lateral olfactory tract (nLOT) is a relatively small component of the cortical pallial amygdala, with peculiar neurogenic, neurochemical and connectivity patterns. Although it has been suggested that it might be involved in non-pheromonal olfactory-guided behaviors, particularly feeding, the functional implications of the nLOT have never been investigated. In view of this fact, we have tackled this subject by performing a series of behavioral tests and by quantifying biological and biochemical parameters in sexually naïve adult male rats that were submitted to bilateral excitotoxic lesions of the nLOT. nLOT-lesioned rats had severe olfactory deficits with inability to detect and discriminate between odors. Additionally, they did not display innate behavioral responses to biologically relevant chemosignals. Specifically, nLOT-lesioned rats did not show avoidance towards predator odors or aggressive behaviors towards intruders, and had severely impaired sexual behavior. In fact, nLOT lesions abolished preference for odors of receptive females, reduced chemoinvestigatory behavior and eliminated mounting behavior. nLOT-lesioned rats had normal circulating levels of testosterone, did not display anxiety- or depressive-like behaviors, and had unimpaired cognitive functions and fear acquisition and memory. Altogether, our results suggest that the nLOT integrity is required for the normal functioning of the olfactory system.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.