ArticleFrontiers in veterinary science2017
Influence of Cellular Composition and Exogenous Activation on Growth Factor and Cytokine Concentrations in Canine Platelet-Rich Plasmas.
Article in Frontiers in veterinary science, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
14 citing papers in PubMed, 27 citations in OpenAlex.
- Exploratory Multivariate Analysis of Mediator Organization in Canine Platelet-Rich Gel Under NSAID Exposure.Gels (Basel, Switzerland) · 2026Article
- A survey of the clinical usage of intra-articular therapeutics in dogs by veterinary practitioners with a focus on non-steroidal therapies.Frontiers in veterinary science · 2026Article
- Evaluation of multiple freeze-thaw cycles on growth factor and cytokine stability in canine platelet lysate: PDGF, TGF-Frontiers in veterinary science · 2026Article
- Arthroscopic PRP gel augmentation at the tendon-bone interface accelerates functional recovery and structural healing in rotator cuff repair: a retrospective cohort study.BMC musculoskeletal disorders · 2025Article
- Plasma and complement proteins are essential for the antimicrobial activity of canine platelet lysate.Frontiers in veterinary science · 2025Article
- Growth factor and cytokine characterization of canine platelet lysate with variable leukocyte concentration, plasma content, and heat-sensitive proteins.Frontiers in veterinary science · 2024Article
- Platelet Lysate for Mesenchymal Stromal Cell Culture in the Canine and Equine Species: Analogous but Not the Same.Animals : an open access journal from MDPI · 2022Article
- Evaluation of Platelet and Leukocyte Counts in Canine Platelet-Rich Plasma Obtained After Successive Blood Collections From the Same Patient and the Effects of Freezing on the Concentration of Growth Factors Present in It.Frontiers in veterinary science · 2022Article
- Evaluation of the Pro-, Anti-Inflammatory, and Anabolic Effects of Autologous Platelet-Rich Gel Supernatants in anVeterinary medicine international · 2022Article
- The Use of Autologous Protein Solution (Pro-StrideVeterinary medicine (Auckland, N.Z.) · 2021Article
- Efficacy of a Semi Automated Commercial Closed System for Autologous Leukocyte- and Platelet-Rich Plasma (l-prp) Production in Dogs: A Preliminary Study.Animals : an open access journal from MDPI · 2020Article
- The Stryker Regenkit PRP Kit Does Not Concentrate Canine Platelets.Frontiers in veterinary science · 2020Article
- Validation and Characterization of Platelet-Rich Plasma in the Feline: A Prospective Analysis.Frontiers in veterinary science · 2020Article
- Assessment of Canine Autologous Conditioned PlasmaFrontiers in veterinary science · 2018Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveThe purposes of this study were to (1) evaluate correlations among platelet, leukocyte, growth factor, and cytokine concentrations in canine platelet-rich plasmas (PRPs) produced from five different canine PRP-concentrating systems and (2) compare the effects of different activation protocols on platelet activation and growth factor release from one of these PRPs.
methodsPRP was made using blood from 15 dogs and each of 5 different PRP systems in a cross-over design. Complete blood counts were performed to quantify platelet and leukocyte concentrations. PRPs were activated, or not, according to manufacturer instructions, and transforming growth factor-β1 (TGF-β1), platelet-derived growth factor-BB (PDGF-BB), vascular endothelial growth factor, and tumor necrosis factor-alpha (TNF-α) were quantified. Differences among platelet, leukocyte, and growth factor concentration were compared among the different systems. Correlations between platelet and anabolic growth factor concentrations were assessed. Subsequently, PRP was made from 12 additional dogs using one of the devices. Each PRP was divided into three aliquots that were activated with calcium chloride (CaCl
resultsThere were statistically significant differences among the PRPs made with difference devices with regard to platelet, leukocyte, TGF-β1, and PDGF-BB concentrations (
conclusionThere are positive correlations between platelet and anabolic growth factor concentrations in canine PRPs. However, intentional platelet activation has a greater effect on growth factor delivery than platelet concentration. Thrombin provides more robust activation than CaCl
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.