Evidence map›Paper›PMID 28424694›Full record

ArticleFrontiers in immunology2017

Immune Responses in the Central Nervous System Are Anatomically Segregated in a Non-Human Primate Model of Human Immunodeficiency Virus Infection.

Barbara Tavano, Vicky Tsipouri, Gareth A D Hardy, Caroline M Royle, Michael R Keegan, Dietmar Fuchs, Steven Patterson, Neil Almond, Neil Berry, Claire Ham and 2 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in immunology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.1field-weighted citation impact, top 55% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 7 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 5 institutions in 2 countries.

Barbara TavanoCentre for Immunology and Vaccinology (CIV), Imperial College London, Chelsea and Westminster Hospital, London, UK.
Vicky TsipouriNIHR Biological Research Unit, Royal Brompton Hospital, London, UK.
Gareth A D HardyCentre for Immunology and Vaccinology (CIV), Imperial College London, Chelsea and Westminster Hospital, London, UK.
Caroline M RoyleCentre for Immunology and Vaccinology (CIV), Imperial College London, Chelsea and Westminster Hospital, London, UK.
Michael R KeeganCentre for Immunology and Vaccinology (CIV), Imperial College London, Chelsea and Westminster Hospital, London, UK.
Dietmar FuchsDivision of Biological Chemistry, Biocenter, Innsbruck Medical University, Innsbruck, Austria.
Steven PattersonCentre for Immunology and Vaccinology (CIV), Imperial College London, Chelsea and Westminster Hospital, London, UK.
Neil AlmondDivision of Virology, National Institute for Biological Standards and Controls (NIBSC), Potters Bar, Hertfordshire, UK.
Neil BerryDivision of Virology, National Institute for Biological Standards and Controls (NIBSC), Potters Bar, Hertfordshire, UK.
Claire HamDivision of Virology, National Institute for Biological Standards and Controls (NIBSC), Potters Bar, Hertfordshire, UK.
Deborah FergusonDivision of Virology, National Institute for Biological Standards and Controls (NIBSC), Potters Bar, Hertfordshire, UK.
Adriano BoassoCentre for Immunology and Vaccinology (CIV), Imperial College London, Chelsea and Westminster Hospital, London, UK.
Imperial College London · GBNational Institute for Biological Standards and Control · GBChelsea and Westminster Hospital · GBInnsbruck Medical University · ATRoyal Brompton Hospital · GB

Funding

Medical Research Council G0600007Medical Research Council G0601201Medical Research Council G9025730
6 · The paper itself

Abstract

The human immunodeficiency virus (HIV) accesses the central nervous system (CNS) early during infection, leading to HIV-associated cognitive impairment and establishment of a viral reservoir. Here, we describe a dichotomy in inflammatory responses in different CNS regions in simian immunodeficiency virus (SIV)-infected macaques, a model for HIV infection. We found increased expression of inflammatory genes and perivascular leukocyte infiltration in the midbrain of SIV-infected macaques. Conversely, the frontal lobe showed downregulation of inflammatory genes associated with interferon-γ and interleukin-6 pathways, and absence of perivascular cuffing. These immunologic alterations were not accompanied by differences in SIV transcriptional activity within the tissue. Altered expression of genes associated with neurotoxicity was observed in both midbrain and frontal lobe. The segregation of inflammatory responses to specific regions of the CNS may both account for HIV-associated neurological symptoms and constitute a critical hurdle for HIV eradication by shielding the CNS viral reservoir from antiviral immunity.

Indexed as

central nervous systemindoleamine (2,3)-dioxygenaseneuroinflammationneurotoxicitysimian immunodeficiency virus

Identifiers

PMID28424694
PMCPMC5371826
OpenAlexW2616772945

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.