ArticleFrontiers in physiology2017
A Rat Immobilization Model Based on Cage Volume Reduction: A Physiological Model for Bed Rest?
Article in Frontiers in physiology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.
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Who cites it
14 citing papers in PubMed, 1 synthesis or guideline pooled it, 29 citations in OpenAlex.
- A Systematic Review of Animal Models of Disuse-Induced Bone Loss.Calcified tissue international · 2021Pooled it
- Context-dependent effects of whole-body vibration on reproductive function and penile tissue integrity in sedentary male rats.Experimental physiology · 2026Article
- The small-cage induced sedentariness in male young rats: evidence from energy expenditure and glucose uptake.Scientific reports · 2026Article
- Sedentary lifestyle induces oxidative stress and atrophy in rat skeletal muscle.Experimental physiology · 2025Article
- Combined sedentarism and high-fat diet induce early signs of kidney injury in C57BL/6J mice.American journal of physiology. Renal physiology · 2025Article
- Short bouts and long-term exercise reduce sedentary-induced bone loss and microstructural changes by modulating bone formation and resorption in healthy young male rats.Scientific reports · 2025Article
- Six months of physical inactivity is insufficient to cause chronic kidney disease in C57BL/6J mice.bioRxiv : the preprint server for biology · 2024Article
- Changes in the Mechanical Properties of Fast and Slow Skeletal Muscle after 7 and 21 Days of Restricted Activity in Rats.International journal of molecular sciences · 2023Article
- Effect of Mechanical Stimuli and Zoledronic Acid on the Femoral Bone Morphology in Rats with Obesity and Limited Mobility.Journal of clinical medicine · 2022Article
- Sarcopenia versus cancer cachexia: the muscle wasting continuum in healthy and diseased aging.Biogerontology · 2021Review
- Mitochondrial Bioenergetics and Turnover during Chronic Muscle Disuse.International journal of molecular sciences · 2021Review
- Preclinical rodent models of physical inactivity-induced muscle insulin resistance: challenges and solutions.Journal of applied physiology (Bethesda, Md. : 1985) · 2021Review
- Absence of MyD88 from Skeletal Muscle Protects Female Mice from Inactivity-Induced Adiposity and Insulin Resistance.Obesity (Silver Spring, Md.) · 2020Article
- Inducing Physical Inactivity in Mice: Preventing Climbing and Reducing Cage Size Negatively Affect Physical Fitness and Body Composition.Frontiers in behavioral neuroscience · 2019Article
Corrections and comments
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Authors and funding
12 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Bed rest has been an established treatment in the past prescribed for critically illness or convalescing patients, in order to preserve their body metabolic resource, to prevent serious complications and to support their rapid path to recovery. However, it has been reported that prolonged bed rest can have detrimental consequences that may delay or prevent the recovery from clinical illness. In order to study disuse-induced changes in muscle and bone, as observed during prolonged bed rest in humans, an innovative new model of muscle disuse for rodents is presented. Basically, the animals are confined to a reduced space designed to restrict their locomotion movements and allow them to drink and eat easily, without generating physical stress. The animals were immobilized for either 7, 14, or 28 days. The immobilization procedure induced a significant decrease of food intake, both at 14 and 28 days of immobilization. The reduced food intake was not a consequence of a stress condition induced by the model since plasma corticosterone levels -an indicator of a stress response- were not altered following the immobilization period. The animals showed a significant decrease in soleus muscle mass, grip force and cross-sectional area (a measure of fiber size), together with a decrease in bone mineral density. The present model may potentially serve to investigate the effects of bed-rest in pathological states characterized by a catabolic condition, such as diabetes or cancer.
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