Evidence map›Paper›PMID 28424621›Full record

ArticleFrontiers in pharmacology2017

Activation of Sirtuin 3 by Silybin Attenuates Mitochondrial Dysfunction in Cisplatin-induced Acute Kidney Injury.

Yin Li, Zengchun Ye, Weiyan Lai, Jialing Rao, Wanbing Huang, Xiaohao Zhang, Ziying Yao, Tanqi Lou

Open access · goldAbstract read
In one paragraph

Article in Frontiers in pharmacology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 61 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
61citing papers in PubMed, 1 pooled it
5.5field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

61 citing papers in PubMed, 1 synthesis or guideline pooled it, 104 citations in OpenAlex.

  1. Pooled it
  2. A HeterogeneousInternational journal of molecular sciences · 2026
    Article
  3. Article
  4. Review
  5. The Role of Sirt3 in Kidney Health and Disease.Pharmaceuticals (Basel, Switzerland) · 2025
    Review
  6. Review
  7. Review
  8. Article
  9. Review
  10. Article
  11. Roles of SIRT3 in aging and aging-related diseases.International journal of biological sciences · 2025
    Review
  12. Review
  13. Review
  14. Review
  15. NAD deficiency contributes to progressive kidney disease in HIV-nephropathy mice.American journal of physiology. Renal physiology · 2024
    Article
  16. Article
  17. Sirtuins in kidney health and disease.Nature reviews. Nephrology · 2024
    Review
  18. Review
  19. Review
  20. Review

1 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Yin LiDepartment of Nephrology, Third Affiliated Hospital, Sun Yat-sen UniversityGuangzhou, China.
Zengchun YeDepartment of Nephrology, Third Affiliated Hospital, Sun Yat-sen UniversityGuangzhou, China.
Weiyan LaiDepartment of Nephrology, Third Affiliated Hospital, Sun Yat-sen UniversityGuangzhou, China.
Jialing RaoDepartment of Nephrology, Third Affiliated Hospital, Sun Yat-sen UniversityGuangzhou, China.
Wanbing HuangDepartment of Nephrology, Third Affiliated Hospital, Sun Yat-sen UniversityGuangzhou, China.
Xiaohao ZhangDepartment of Nephrology, Third Affiliated Hospital, Sun Yat-sen UniversityGuangzhou, China.
Ziying YaoDepartment of Nephrology, Third Affiliated Hospital, Sun Yat-sen UniversityGuangzhou, China.
Tanqi LouDepartment of Nephrology, Third Affiliated Hospital, Sun Yat-sen UniversityGuangzhou, China.
Third Affiliated Hospital of Sun Yat-sen University · CNSun Yat-sen University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Silybin is a secondary metabolite isolated from the seeds of blessed milk thistle (

Indexed as

apoptosiscisplatin-induced acute kidney diseasemitochondriaregenerationsilybinSIRT3

Identifiers

PMID28424621
PMCPMC5380914
OpenAlexW2605255460

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.