ArticleFrontiers in cellular neuroscience2017
Geometrical Determinants of Neuronal Actin Waves.
Article in Frontiers in cellular neuroscience, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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6 citing papers in PubMed, 12 citations in OpenAlex.
- Article
- ECM-Mimetic Nylon Nanofiber Scaffolds for Neurite Growth Guidance.Nanomaterials (Basel, Switzerland) · 2021Article
- Article
- Dependence and Homeostasis of Membrane Impedance on Cell Morphology in Cultured Hippocampal Neurons.Scientific reports · 2018Article
- The nano-architecture of the axonal cytoskeleton.Nature reviews. Neuroscience · 2017Review
- Actin Waves Do Not Boost Neurite Outgrowth in the Early Stages of Neuron Maturation.Frontiers in cellular neuroscience · 2017Article
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Authors and funding
7 authors at 5 institutions in 3 countries.
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No grant is acknowledged in the PubMed record.
Abstract
Hippocampal neurons produce in their early stages of growth propagative, actin-rich dynamical structures called actin waves. The directional motion of actin waves from the soma to the tip of neuronal extensions has been associated with net forward growth, and ultimately with the specification of neurites into axon and dendrites. Here, geometrical cues are used to control actin wave dynamics by constraining neurons on adhesive stripes of various widths. A key observable, the average time between the production of consecutive actin waves, or mean inter-wave interval (IWI), was identified. It scales with the neurite width, and more precisely with the width of the proximal segment close to the soma. In addition, the IWI is independent of the total number of neurites. These two results suggest a mechanistic model of actin wave production, by which the material conveyed by actin waves is assembled in the soma until it reaches the threshold leading to the initiation and propagation of a new actin wave. Based on these observations, we formulate a predictive theoretical description of actin wave-driven neuronal growth and polarization, which consistently accounts for different sets of experiments.
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