ArticleFrontiers in neuroscience2017
Defensive Vocalizations and Motor Asymmetry Triggered by Disinhibition of the Periaqueductal Gray in Non-human Primates.
Article in Frontiers in neuroscience, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 19 citations in OpenAlex.
- Article
- Article
- Pharmacological Inhibition of the Nucleus Accumbens Increases Dyadic Social Interaction in Macaques.eNeuro · 2024Article
- Prefrontal cortex interactions with the amygdala in primates.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2022Review
- The Role of the Thalamus in Post-Traumatic Stress Disorder.International journal of molecular sciences · 2021Review
- Circuit and synaptic organization of forebrain-to-midbrain pathways that promote and suppress vocalization.eLife · 2020Article
- Dysregulation of behavioral and autonomic responses to emotional and social stimuli following bidirectional pharmacological manipulation of the basolateral amygdala in macaques.Neuropharmacology · 2020Article
- The influence of subcortical shortcuts on disordered sensory and cognitive processing.Nature reviews. Neuroscience · 2020Review
- Inhibition of the Deep and Intermediate Layers of the Superior Colliculus Disrupts Sensorimotor Gating in Monkeys.Frontiers in behavioral neuroscience · 2020Article
- The Role of the Amygdala and the Ventromedial Prefrontal Cortex in Emotional Regulation: Implications for Post-traumatic Stress Disorder.Neuropsychology review · 2019Review
- Heightened Defensive Responses Following Subtotal Lesions of Macaque Orbitofrontal Cortex.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2019Article
- Article
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Rapid and reflexive responses to threats are present across phylogeny. The neural circuitry mediating reflexive defense reactions has been well-characterized in a variety of species, for example, in rodents and cats, the detection of and species-typical response to threats is mediated by a network of structures including the midbrain tectum (deep and intermediate layers of the superior colliculus [DLSC]), periaqueductal gray (PAG), and forebrain structures such as the amygdala and hypothalamus. However, relatively little is known about the functional architecture of defense circuitry in primates. We have previously reported that pharmacological activation of the DLSC evokes locomotor asymmetry, defense-associated vocalizations, cowering behavior, escape responses, and attack of inanimate objects (Holmes et al., 2012; DesJardin et al., 2013; Forcelli et al., 2016). Here, we sought to determine if pharmacological activation of the PAG would induce a similar profile of responses. We activated the PAG in three awake, behaving macaques by microinfusion of GABA-A receptor antagonist, bicuculline methiodide. Activation of PAG evoked defense-associated vocalizations and postural/locomotor asymmetry, but not motor defense responses (e.g., cowering, escape behavior). These data suggest a partial dissociation between the role of the PAG and the DLSC in the defense network of macaques, but a general conservation of the role of PAG in defense responses across species.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.