ReviewFrontiers in neuroscience2017
Contribution of Autonomic Reflexes to the Hyperadrenergic State in Heart Failure.
Review in Frontiers in neuroscience, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Short-term Effects of High Thoracic Epidural Blockade in Patients With Ischemic Heart Disease and Heart Failure: A Systematic Review and Data Synthesis.Reviews in cardiovascular medicine · 2025Pooled it
- Autonomic Neuromodulation Acutely Ameliorates Left Ventricular Strain in Humans.Journal of cardiovascular translational research · 2019Trial
- Neural Control of Tissue Perfusion: Emerging Evidence and Beyond.Current hypertension reports · 2026Review
- Artificial Intelligence-Guided Neuromodulation in Heart Failure with Preserved and Reduced Ejection Fraction: Mechanisms, Evidence, and Future Directions.Journal of cardiovascular development and disease · 2025Review
- Low-level auricular vagus nerve stimulation lowers blood pressure and heart rate in paroxysmal atrial fibrillation patients: a self-controlled study.Frontiers in neuroscience · 2025Article
- β-adrenergic regulation of CaBiophysics reports · 2024Article
- The Sympathetic Nervous System in Hypertensive Heart Failure with Preserved LVEF.Journal of clinical medicine · 2023Review
- Altered Heart Rate Turbulence and Variability Parameters Predict 1-Year Mortality in Heart Failure with Preserved Ejection Fraction.Journal of cardiovascular development and disease · 2022Article
- Twenty-four-hour blood pressure and heart rate variability are reduced in patients on left ventricular assist device support.The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation · 2022Article
- Cardiac Spinal Afferent Denervation Attenuates Renal Dysfunction in Rats With Cardiorenal Syndrome Type 2.JACC. Basic to translational science · 2022Article
- The impact of obesity on the regulation of muscle blood flow during exercise in patients with heart failure with a preserved ejection fraction.Journal of applied physiology (Bethesda, Md. : 1985) · 2022Article
- Sympathetic activation in heart failure with reduced and mildly reduced ejection fraction: the role of aetiology.ESC heart failure · 2021Article
- Oscillatory Pattern of Sympathetic Nerve Bursts Is Associated With Baroreflex Function in Heart Failure Patients With Reduced Ejection Fraction.Frontiers in neuroscience · 2021Article
- Cardiovascular responses to rhythmic handgrip exercise in heart failure with preserved ejection fraction.Journal of applied physiology (Bethesda, Md. : 1985) · 2020Article
- Effect of SGLT2 Inhibitors on the Sympathetic Nervous System and Blood Pressure.Current cardiology reports · 2019Review
- Cardiac and Peripheral Autonomic Responses to Orthostatic Stress During Transcutaneous Vagus Nerve Stimulation in Healthy Subjects.Journal of clinical medicine · 2019Article
- Absence of synemin in mice causes structural and functional abnormalities in heart.Journal of molecular and cellular cardiology · 2018Article
- Arrhythmogenic Mechanisms in Heart Failure: Linking β-Adrenergic Stimulation, Stretch, and Calcium.Frontiers in physiology · 2018Review
- Pyridostigmine Improves the Effects of Resistance Exercise Training after Myocardial Infarction in Rats.Frontiers in physiology · 2018Article
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Heart failure (HF) is a complex syndrome representing the clinical endpoint of many cardiovascular diseases of different etiology. Given its prevalence, incidence and social impact, a better understanding of HF pathophysiology is paramount to implement more effective anti-HF therapies. Based on left ventricle (LV) performance, HF is currently classified as follows: (1) with reduced ejection fraction (HFrEF); (2) with mid-range EF (HFmrEF); and (3) with preserved EF (HFpEF). A central tenet of HFrEF pathophysiology is adrenergic hyperactivity, featuring increased sympathetic nerve discharge and a progressive loss of rhythmical sympathetic oscillations. The role of reflex mechanisms in sustaining adrenergic abnormalities during HFrEF is increasingly well appreciated and delineated. However, the same cannot be said for patients affected by HFpEF or HFmrEF, whom also present with autonomic dysfunction. Neural mechanisms of cardiovascular regulation act as "controller units," detecting and adjusting for changes in arterial blood pressure, blood volume, and arterial concentrations of oxygen, carbon dioxide and pH, as well as for humoral factors eventually released after myocardial (or other tissue) ischemia. They do so on a beat-to-beat basis. The central dynamic integration of all these afferent signals ensures homeostasis, at rest and during states of physiological or pathophysiological stress. Thus, the net result of information gathered by each controller unit is transmitted by the autonomic branch using two different codes:
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