ArticleScientific reports2017
The impact of host sex on the outcome of co-infection.
Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 8 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
8 citing papers in PubMed, 21 citations in OpenAlex.
- Is there a sicker sex? Dose relationships modify male-female differences in infection prevalence.Proceedings. Biological sciences · 2024Article
- Dissecting genetic and sex-specific sources of host heterogeneity in pathogen shedding and spread.PLoS pathogens · 2021Article
- Pathogen exposure reduces sexual dimorphism in a host's upper thermal limits.Ecology and evolution · 2020Article
- Features and associated factors of bacterial skin infections in hospitalized patients with pemphigus: a single-center retrospective study.Annals of clinical microbiology and antimicrobials · 2020Article
- Sublethal effects of natural parasitism act through maternal, but not paternal, reproductive success in a wild population.Ecology · 2019Article
- Can pathogens optimize both transmission and dispersal by exploiting sexual dimorphism in their hosts?Biology letters · 2019Article
- Linking sex differences to the evolution of infectious disease life-histories.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2018Article
- When males outlive females: Sex-specific effects of temperature on lifespan in a cyclic parthenogen.Ecology and evolution · 2018Article
Corrections and comments
- Erratum issued
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Males and females vary in many characteristics that typically underlie how well a host is able to fight infection, such as body-size, immune capacity, or energy availability. Although well studied in the context of sexual signalling, there is now growing recognition that these differences can influence aspects of pathogen evolution as well. Here we consider how co-infection between multiple pathogen strains is shaped by male-female differences. In natural populations, infections by more than one pathogen strain or species are believed to be a widespread occurrence. Using the water flea, Daphnia magna, we exposed genetically identical males and females to replicated bacterial co-infections. We found that pathogen transmission and virulence were much higher in females. However, males did not simply lower average pathogen fitness, but rather the influence of co-infection was more varied and less defined than in females. We discuss how pathogens may have more fitness benefits to gain, and consequently to lose, when infecting one sex over the other.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.