ArticleScientific reports2017
The Chemical Characterization of Nigerian Propolis samples and Their Activity Against Trypanosoma brucei.
Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
28 citing papers in PubMed, 67 citations in OpenAlex.
- Chemical Profiling and Geographic Differentiation of Ugandan Propolis by GC-MS Through Chemometric Modelling.Molecules (Basel, Switzerland) · 2025Article
- Interventions for Neglected Diseases Caused by Kinetoplastid Parasites: A One Health Approach to Drug Discovery, Development, and Deployment.Pharmaceuticals (Basel, Switzerland) · 2025Review
- Therapeutic Potential of Propolis and Royal Jelly in Encephalitozoon Intestinalis Infection: An in Vitro Study.Acta parasitologica · 2025Article
- Phytochemical profiling and characterization of flavonoid derivatives from propolis sample and investigation of cytotoxic and antiprotozoal activities.Scientific reports · 2024Article
- Hive Products: Composition, Pharmacological Properties, and Therapeutic Applications.Pharmaceuticals (Basel, Switzerland) · 2024Review
- Human schistosomiasis in Nigeria: present status, diagnosis, chemotherapy, and herbal medicines.Parasitology research · 2023Review
- Exploring the Functional Properties of Propolis, Geopropolis, and Cerumen, with a Special Emphasis on Their Antimicrobial Effects.Foods (Basel, Switzerland) · 2023Review
- The Activity of Red Nigerian Propolis and Some of Its Components againstMolecules (Basel, Switzerland) · 2023Article
- Propolis: An update on its chemistry and pharmacological applications.Chinese medicine · 2022Review
- Portuguese Propolis Antitumoral Activity in Melanoma Involves ROS Production and Induction of Apoptosis.Molecules (Basel, Switzerland) · 2022Article
- The Antiprotozoal Activity of Papua New Guinea Propolis and Its Triterpenes.Molecules (Basel, Switzerland) · 2022Article
- Cytotoxicity effect of honey, bee pollen, and propolis from seven stingless bees in some cancer cell lines.Saudi journal of biological sciences · 2021Article
- Pharmaceutical Prospects of Bee Products: Special Focus on Anticancer, Antibacterial, Antiviral, and Antiparasitic Properties.Antibiotics (Basel, Switzerland) · 2021Review
- Activity of Compounds from Temperate Propolis againstMolecules (Basel, Switzerland) · 2021Article
- Antiviral, Antibacterial, Antifungal, and Antiparasitic Properties of Propolis: A Review.Foods (Basel, Switzerland) · 2021Review
- Chemical characterization of Saudi propolis and its antiparasitic and anticancer properties.Scientific reports · 2021Article
- Antitrypanosomal and Antileishmanial Activity of Chalcones and Flavanones fromPathogens (Basel, Switzerland) · 2021Article
- Consolidating and Upscaling Molecular Research Capacity in Nigeria: On Who's Account?Frontiers in research metrics and analytics · 2021Review
- Article
- Novel flavanones with anti-trypanosomal activity isolated from Zambian and Tanzanian propolis samples.International journal for parasitology. Drugs and drug resistance · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Profiling of extracts from twelve propolis samples collected from eight regions in Nigeria was carried out using high performance liquid chromatography (LC) coupled with evaporative light scattering (ELSD), ultraviolet detection (UV) and mass spectrometry (MS), gas chromatography mass spectrometry (GC-MS) and nuclear magnetic resonance spectroscopy (NMR). Principal component analysis (PCA) of the processed LC-MS data demonstrated the varying chemical composition of the samples. Most of the samples were active against Trypanosoma b. brucei with the highest activity being in the samples from Southern Nigeria. The more active samples were fractionated in order to isolate the component(s) responsible for their activity using medium pressure liquid chromatography (MPLC). Three xanthones, 1,3,7-trihydroxy-2,8-di-(3-methylbut-2-enyl)xanthone, 1,3,7-trihydroxy-4,8-di-(3-methylbut-2-enyl)xanthone a previously undescribed xanthone and three triterpenes: ambonic acid, mangiferonic acid and a mixture of α-amyrin with mangiferonic acid (1:3) were isolated and characterised by NMR and LC-MS. These compounds all displayed strong inhibitory activity against T.b. brucei but none of them had higher activity than the crude extracts. Partial least squares (PLS) modelling of the anti-trypanosomal activity of the sample extracts using the LC-MS data indicated that high activity in the extracts, as judged from LCMS
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.