ArticleScientific reports2017
Significance of genetic polymorphisms in long non-coding RNA AC079767.4 in tuberculosis susceptibility and clinical phenotype in Western Chinese Han population.
Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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20 citing papers in PubMed, 28 citations in OpenAlex.
- A New Risk Polymorphism rs10403848 of CARD8 Significantly Associated with Psoriasis Vulgaris in Northeastern China.BioMed research international · 2020Trial
- Different MicroRNAs expression inRNA biology · 2026Review
- Long non-coding RNAs in tuberculosis: Immune regulation and clinical biomarker potential.iScience · 2026Review
- Long non-coding RNA transcripts inNon-coding RNA research · 2025Review
- Advances of Long Non-Coding RNAs as Potential Biomarkers for Tuberculosis: New Hope for Diagnosis?Pharmaceutics · 2023Review
- Long Non-coding RNAs in Tuberculosis: From Immunity to Biomarkers.Frontiers in microbiology · 2022Review
- Clinical relevance of genetic polymorphisms in WNT signaling pathway (Frontiers in immunology · 2022Article
- Clinical relevance of vitamin B12 level and vitamin B12 metabolic gene variation in pulmonary tuberculosis.Frontiers in immunology · 2022Article
- Screening of Long Non-coding RNAs Biomarkers for the Diagnosis of Tuberculosis and Preliminary Construction of a Clinical Diagnosis Model.Frontiers in microbiology · 2022Article
- Association of ficolin-1 and ficolin-3 gene variation and pulmonary tuberculosis susceptibility in a Chinese population.Journal of clinical laboratory analysis · 2021Article
- Integrated analysis of lncRNA, miRNA and mRNA profiles reveals potential lncRNA functions during early HIV infection.Journal of translational medicine · 2021Article
- Article
- The dominant model analysis of Sirt3 genetic variants is associated with susceptibility to tuberculosis in a Chinese Han population.Molecular genetics and genomics : MGG · 2020Article
- Significance of LncRNA CASC8 genetic polymorphisms on the tuberculosis susceptibility in Chinese population.Journal of clinical laboratory analysis · 2020Article
- Inflammatory response is modulated by lincRNACox2 via the NF‑κB pathway in macrophages infected by Mycobacterium tuberculosis.Molecular medicine reports · 2020Article
- Association Study of ANRIL Genetic Variants and Multiple Sclerosis.Journal of molecular neuroscience : MN · 2018Article
- Association ofBioMed research international · 2018Article
- Variation in the Untranslated Genome and Susceptibility to Infections.Frontiers in immunology · 2018Review
- Clinical relevance ofOncotarget · 2017Article
- Screening and identification of lncRNAs as potential biomarkers for pulmonary tuberculosis.Scientific reports · 2017Article
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Authors and funding
9 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Recent studies have implicated long non-coding RNA, AC079767.4, as a highly susceptible gene in tuberculosis. The aim of the study was to preliminarily explore the possible association of single nucleotide polymorphisms (SNPs) in AC079767.4 gene with clinical phenotypes and TB susceptibility in Western Chinese Han population. The improved multiplex ligation detection reaction (iMLDR) method was employed to genotype 4 SNPs in AC079767.4 in 554 tuberculosis patients and 561 healthy individuals. In subgroup analysis, only the C allele for rs12477677 was associated with the decreased susceptibility to pulmonary TB with a p-value of 0.026, but p-value was 0.103 after Bonferroni correction. In total samples, haplotype [ACAC], representing four AC079767.4 variants, was found to slightly decrease TB risk (p = 0.045). Furthermore, patients with the CC genotype of rs12477677 were correlated with fewer occurrences of fever (p = 0.016), while patients carrying the T allele were associated with lower levels of ESR in the dominant model of rs1055229 (p = 0.021). For the first time, we reported the potential susceptibility and clinical traits of tuberculosis with lncRNA variants in the Western Han Chinese population. Our data indicate AC079767.4 polymorphisms may potentially act as novel biomarkers for tuberculosis diagnostic and therapeutic purposes.
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