ArticleScientific reports2017
Effect of handgrip on coronary artery disease and myocardial infarction: a Mendelian randomization study.
Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers, 2 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
32 citing papers in PubMed, 2 syntheses or guidelines pooled it, 54 citations in OpenAlex.
- Association between serum uric acid and prostate cancer risk in East Asian populations: a Mendelian randomization study.European journal of nutrition · 2023Pooled it
- Cardiorespiratory fitness, muscular strength and risk of type 2 diabetes: a systematic review and meta-analysis.Diabetologia · 2019Pooled it
- Biological Sex and the Association Between Grip Strength and Cardiovascular Disease: a Scoping Review.Canadian geriatrics journal : CGJ · 2025Review
- Genetically predicted endogenous sex hormone levels with risk of eczema or dermatitis.Hormones (Athens, Greece) · 2025Article
- Observational and genetic associations between cardiorespiratory fitness and age-related diseases: longitudinal analyses in the UK Biobank study.The EPMA journal · 2024Article
- Association of relative hand grip strength with myocardial infarction and angina pectoris in the Korean population: a large-scale cross-sectional study.BMC public health · 2024Article
- Creatine Acts as a Mediator of the Causal Effect of Obesity on Puberty Onset in Girls: Evidence from Mediation Mendelian Randomization Study.Metabolites · 2024Article
- Associations between dietary habits and bipolar disorder: a diet-wide mendelian randomization study.Frontiers in psychiatry · 2024Article
- Prediabetes-Associated Changes in Skeletal Muscle Function and Their Possible Links with Diabetes: A Literature Review.International journal of molecular sciences · 2023Review
- Detecting potential causal relationship between inflammatory bowel disease and rosacea using bi-directional Mendelian randomization.Scientific reports · 2023Article
- Article
- Handgrip strength is associated with risks of new-onset stroke and heart disease: results from 3 prospective cohorts.BMC geriatrics · 2023Article
- Association of Multiple Cardiovascular Risk Factors with Musculoskeletal Function in Acute Coronary Syndrome Ward Inpatients.Healthcare (Basel, Switzerland) · 2023Article
- Associations of alcohol and coffee with colorectal cancer risk in East Asian populations: a Mendelian randomization study.European journal of nutrition · 2023Article
- Association between sarcopenia-related traits and cardiovascular diseases: a bi-directional Mendelian randomization study.Frontiers in endocrinology · 2023Article
- Handgrip strength is associated with adverse outcomes in patients hospitalized for COVID-19-associated pneumonia.Internal and emergency medicine · 2022Article
- Association of Handgrip Strength with Diabetes Mellitus in Korean Adults According to Sex.Diagnostics (Basel, Switzerland) · 2022Article
- Assessment of causal associations between handgrip strength and cardiovascular diseases: A two sample mendelian randomization study.Frontiers in cardiovascular medicine · 2022Article
- Sarcopenia and coronary heart disease synergistically increase the risk of new onset depressive symptoms in older adults.BMC geriatrics · 2021Article
- Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Observational studies have reported an association of handgrip strength with risk of cardiovascular disease. However, residual confounding and reverse causation may have influenced these findings. A Mendelian randomization (MR) study was conducted to examine whether handgrip is causally associated with cardiovascular disease. Two single nucleotide polymorphisms (SNPs), rs3121278 and rs752045, were used as the genetic instruments for handgrip. The effect of each SNP on coronary artery disease/myocardial infarction (CAD/MI) was weighted by its effect on handgrip strength, and estimates were pooled to provide a summary measure for the effect of increased handgrip on risk of CAD/MI. MR analysis showed that higher grip strength reduces risk for CAD/MI, with 1-kilogram increase in genetically determined handgrip reduced odds of CAD by 6% (odds ratio (OR) = 0.94, 95% confidence interval (CI) 0.91-0.99, P = 0.01), and reduced odds of MI by 7% (OR = 0.93, 95% CI 0.89-0.98, P = 0.003). No association of grip strength with type 2 diabetes, body mass index, LDL- and HDL-cholesterol, triglycerides and fasting glucose was found. The inverse causal relationship between handgrip and the risk of CAD or MI suggests that promoting physical activity and resistance training to improve muscle strength may be important for cardiovascular health.
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