ArticleOncotarget2017
Circular RNA hsa-circ-0016347 promotes proliferation, invasion and metastasis of osteosarcoma cells.
Article in Oncotarget, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
46 citing papers in PubMed, 84 citations in OpenAlex.
- Circular RNA vaccines: Pioneering the next-gen cancer immunotherapy.Cancer pathogenesis and therapy · 2025Review
- Osteosarcoma in a ceRNET perspective.Journal of biomedical science · 2024Review
- Role of non-coding RNA in exosomes for the diagnosis and treatment of osteosarcoma.Frontiers in oncology · 2024Review
- Dysregulation of global circular RNA abundance regulated by spliceosomes predicts prognosis in hepatocellular carcinoma.Hepatology communications · 2022Article
- Differentially expression and function of circular RNAs in ovarian cancer stem cells.Journal of ovarian research · 2022Article
- Navigating the genomic instability mine field of osteosarcoma to better understand implications of non-coding RNAs.Biocell : official journal of the Sociedades Latinoamericanas de Microscopia Electronica ... et. al · 2022Article
- Circular RNA in cancer development and immune regulation.Journal of cellular and molecular medicine · 2022Review
- Review
- Article
- Insights Into the Role of CircRNAs: Biogenesis, Characterization, Functional, and Clinical Impact in Human Malignancies.Frontiers in cell and developmental biology · 2021Review
- CircSAMD4A regulates cell progression and epithelial‑mesenchymal transition by sponging miR‑342‑3p via the regulation of FZD7 expression in osteosarcoma.International journal of molecular medicine · 2020Article
- Circular RNAs: epigenetic regulators in cancerous and noncancerous skin diseases.Cancer gene therapy · 2020Review
- circDLPAG4/HECTD1 mediates ischaemia/reperfusion injury in endothelial cells via ER stress.RNA biology · 2020Article
- Circular RNA LARP4 correlates with decreased Enneking stage, better histological response, and prolonged survival profiles, and it elevates chemosensitivity to cisplatin and doxorubicin via sponging microRNA-424 in osteosarcoma.Journal of clinical laboratory analysis · 2020Article
- Extracellular nanovesicles-transmitted circular RNA has_circ_0000190 suppresses osteosarcoma progression.Journal of cellular and molecular medicine · 2020Article
- Therapeutic Potential of Circular RNAs in Osteosarcoma.Frontiers in oncology · 2020Review
- Circular RNA expression pattern in cisplatin-resistant osteosarcoma cells.Translational cancer research · 2020Article
- Emerging Roles and Potential Biological Value of CircRNA in Osteosarcoma.Frontiers in oncology · 2020Review
- Circular RNAs in Embryogenesis and Cell Differentiation With a Focus on Cancer Development.Frontiers in cell and developmental biology · 2020Review
- Up-Regulation of Hsa_circ_0008792 Inhibits Osteosarcoma Cell Invasion and Migration and Promotes Apoptosis by Regulating Hsa-miR-711/ZFP1.OncoTargets and therapy · 2020Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Circular RNAs (circRNAs) are a novel class of non-coding RNA which have recently shown huge capabilities in the regulation of gene expression at the post-transcriptional level. Growing evidence has indicated that circRNAs could serve as competing endogenous RNAs (ceRNAs) to bind with microRNAs (miRNAs) and to inhibit the activity and function of the targeted miRNAs. Here, we demonstrated that circ-0016347 acted as a positive regulator in osteosarcoma cells proliferation and invasion. Moreover, circ-0016347 was identified as a sponge of miR-214 that upregulated the expression of caspase-1, which is the functional target of miR-214. Our study provides novel insight into the regulatory mechanism of circ-0016347 and its downstream targets in proliferation, invasion and metastasis of osteosarcoma cells, which will facilitate further development in the therapy of osteosarcoma.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.