Evidence map›Paper›PMID 28424281›Full record

ArticleJournal of virology2017

Distinct Roles of Vaccinia Virus NF-κB Inhibitor Proteins A52, B15, and K7 in the Immune Response.

Mauro Di Pilato, Ernesto Mejías-Pérez, Carlos Oscar S Sorzano, Mariano Esteban

Open access · bronzeAbstract read
In one paragraph

Article in Journal of virology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed
2.2field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed, 39 citations in OpenAlex.

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  11. Poxvirus Interactions with the Host Ubiquitin System.Pathogens (Basel, Switzerland) · 2021
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  13. Concurrent expression ofMolecular therapy oncolytics · 2021
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  15. Poxviral Strategies to Overcome Host Cell Apoptosis.Pathogens (Basel, Switzerland) · 2020
    Review
  16. Review
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  19. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Mauro Di PilatoDepartment of Molecular and Cellular Biology, Centro Nacional de Biotecnología (CNB-CSIC), Madrid, Spain mdipilato@mgh.harvard.edu mesteban@cnb.csic.es.
Ernesto Mejías-PérezDepartment of Molecular and Cellular Biology, Centro Nacional de Biotecnología (CNB-CSIC), Madrid, Spain.
Carlos Oscar S SorzanoBiocomputing Unit, Centro Nacional de Biotecnología (CNB-CSIC), Madrid, Spain.
Mariano EstebanDepartment of Molecular and Cellular Biology, Centro Nacional de Biotecnología (CNB-CSIC), Madrid, Spain mdipilato@mgh.harvard.edu mesteban@cnb.csic.es.
Centro Nacional de Biotecnología · ES

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Poxviruses use a complex strategy to escape immune control, by expressing immunomodulatory proteins that could limit their use as vaccine vectors. To test the role of poxvirus NF-κB pathway inhibitors A52, B15, and K7 in immunity, we deleted their genes in an NYVAC (New York vaccinia virus) strain that expresses HIV-1 clade C antigens. After infection of mice, ablation of the

Indexed as

Host-Pathogen InteractionsImmune EvasionAnimalsCell MovementCytokinesDendritic CellsDisease Models, AnimalGene DeletionKiller Cells, NaturalMiceNeutrophilsNF-kappa B p50 SubunitVacciniaVaccinia virusViral ProteinsA52R protein, vaccinia virusB15R protein, Vaccinia virusCytokinesK7R protein, Vaccinia virusNF-kappa B p50 SubunitNfkb1 protein, mouseViral Proteinsadaptive immunityhuman immunodeficiency virusimmunomodulationinnate immunityNF-κBNYVACpoxvirusT cell immunityvaccinesvaccinia virus

Identifiers

PMID28424281
PMCPMC5469261
OpenAlexW2605971075

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.