Evidence map›Paper›PMID 28424270›Full record

ArticleNeurology2017

Significance of circadian rhythms in severely brain-injured patients: A clue to consciousness?

Christine Blume, Julia Lechinger, Nayantara Santhi, Renata del Giudice, Maria-Teresa Gnjezda, Gerald Pichler, Monika Scarpatetti, Johann Donis, Gabriele Michitsch, Manuel Schabus

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neurology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed
5.5field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

28 citing papers in PubMed, 71 citations in OpenAlex.

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  6. Prognosis of consciousness disorders in the intensive care unit.Presse medicale (Paris, France : 1983) · 2023
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  20. Effects of light on human circadian rhythms, sleep and mood.Somnologie : Schlafforschung und Schlafmedizin = Somnology : sleep research and sleep medicine · 2019
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 2 countries.

Christine BlumeFrom the Laboratory for Sleep, Cognition and Consciousness Research, Department of Psychology (C.B., J.L., R.d.G., M.-T.G., M. Schabus), and Centre for Cognitive Neuroscience Salzburg (CCNS) (C.B., J.L., R.d.G., M. Schabus), University of Salzburg, Austria; Surrey Sleep Research Centre (N.S.), Faculty of Health and Medical Sciences, University of Surrey, UK; Albert Schweitzer Clinic (G.P., M. Scarpatetti), Apallic Care Unit, Geriatric Health Centres of the City of Graz; and Neurologische Abteilung mit Wachkomabetreuung (J.D., G.M.), Pflegewohnhaus Donaustadt Wien, Vienna, Austria. christine.blume@sbg.ac.at.
Julia LechingerFrom the Laboratory for Sleep, Cognition and Consciousness Research, Department of Psychology (C.B., J.L., R.d.G., M.-T.G., M. Schabus), and Centre for Cognitive Neuroscience Salzburg (CCNS) (C.B., J.L., R.d.G., M. Schabus), University of Salzburg, Austria; Surrey Sleep Research Centre (N.S.), Faculty of Health and Medical Sciences, University of Surrey, UK; Albert Schweitzer Clinic (G.P., M. Scarpatetti), Apallic Care Unit, Geriatric Health Centres of the City of Graz; and Neurologische Abteilung mit Wachkomabetreuung (J.D., G.M.), Pflegewohnhaus Donaustadt Wien, Vienna, Austria.
Nayantara SanthiFrom the Laboratory for Sleep, Cognition and Consciousness Research, Department of Psychology (C.B., J.L., R.d.G., M.-T.G., M. Schabus), and Centre for Cognitive Neuroscience Salzburg (CCNS) (C.B., J.L., R.d.G., M. Schabus), University of Salzburg, Austria; Surrey Sleep Research Centre (N.S.), Faculty of Health and Medical Sciences, University of Surrey, UK; Albert Schweitzer Clinic (G.P., M. Scarpatetti), Apallic Care Unit, Geriatric Health Centres of the City of Graz; and Neurologische Abteilung mit Wachkomabetreuung (J.D., G.M.), Pflegewohnhaus Donaustadt Wien, Vienna, Austria.
Renata del GiudiceFrom the Laboratory for Sleep, Cognition and Consciousness Research, Department of Psychology (C.B., J.L., R.d.G., M.-T.G., M. Schabus), and Centre for Cognitive Neuroscience Salzburg (CCNS) (C.B., J.L., R.d.G., M. Schabus), University of Salzburg, Austria; Surrey Sleep Research Centre (N.S.), Faculty of Health and Medical Sciences, University of Surrey, UK; Albert Schweitzer Clinic (G.P., M. Scarpatetti), Apallic Care Unit, Geriatric Health Centres of the City of Graz; and Neurologische Abteilung mit Wachkomabetreuung (J.D., G.M.), Pflegewohnhaus Donaustadt Wien, Vienna, Austria.
Maria-Teresa GnjezdaFrom the Laboratory for Sleep, Cognition and Consciousness Research, Department of Psychology (C.B., J.L., R.d.G., M.-T.G., M. Schabus), and Centre for Cognitive Neuroscience Salzburg (CCNS) (C.B., J.L., R.d.G., M. Schabus), University of Salzburg, Austria; Surrey Sleep Research Centre (N.S.), Faculty of Health and Medical Sciences, University of Surrey, UK; Albert Schweitzer Clinic (G.P., M. Scarpatetti), Apallic Care Unit, Geriatric Health Centres of the City of Graz; and Neurologische Abteilung mit Wachkomabetreuung (J.D., G.M.), Pflegewohnhaus Donaustadt Wien, Vienna, Austria.
Gerald PichlerFrom the Laboratory for Sleep, Cognition and Consciousness Research, Department of Psychology (C.B., J.L., R.d.G., M.-T.G., M. Schabus), and Centre for Cognitive Neuroscience Salzburg (CCNS) (C.B., J.L., R.d.G., M. Schabus), University of Salzburg, Austria; Surrey Sleep Research Centre (N.S.), Faculty of Health and Medical Sciences, University of Surrey, UK; Albert Schweitzer Clinic (G.P., M. Scarpatetti), Apallic Care Unit, Geriatric Health Centres of the City of Graz; and Neurologische Abteilung mit Wachkomabetreuung (J.D., G.M.), Pflegewohnhaus Donaustadt Wien, Vienna, Austria.
Monika ScarpatettiFrom the Laboratory for Sleep, Cognition and Consciousness Research, Department of Psychology (C.B., J.L., R.d.G., M.-T.G., M. Schabus), and Centre for Cognitive Neuroscience Salzburg (CCNS) (C.B., J.L., R.d.G., M. Schabus), University of Salzburg, Austria; Surrey Sleep Research Centre (N.S.), Faculty of Health and Medical Sciences, University of Surrey, UK; Albert Schweitzer Clinic (G.P., M. Scarpatetti), Apallic Care Unit, Geriatric Health Centres of the City of Graz; and Neurologische Abteilung mit Wachkomabetreuung (J.D., G.M.), Pflegewohnhaus Donaustadt Wien, Vienna, Austria.
Johann DonisFrom the Laboratory for Sleep, Cognition and Consciousness Research, Department of Psychology (C.B., J.L., R.d.G., M.-T.G., M. Schabus), and Centre for Cognitive Neuroscience Salzburg (CCNS) (C.B., J.L., R.d.G., M. Schabus), University of Salzburg, Austria; Surrey Sleep Research Centre (N.S.), Faculty of Health and Medical Sciences, University of Surrey, UK; Albert Schweitzer Clinic (G.P., M. Scarpatetti), Apallic Care Unit, Geriatric Health Centres of the City of Graz; and Neurologische Abteilung mit Wachkomabetreuung (J.D., G.M.), Pflegewohnhaus Donaustadt Wien, Vienna, Austria.
Gabriele MichitschFrom the Laboratory for Sleep, Cognition and Consciousness Research, Department of Psychology (C.B., J.L., R.d.G., M.-T.G., M. Schabus), and Centre for Cognitive Neuroscience Salzburg (CCNS) (C.B., J.L., R.d.G., M. Schabus), University of Salzburg, Austria; Surrey Sleep Research Centre (N.S.), Faculty of Health and Medical Sciences, University of Surrey, UK; Albert Schweitzer Clinic (G.P., M. Scarpatetti), Apallic Care Unit, Geriatric Health Centres of the City of Graz; and Neurologische Abteilung mit Wachkomabetreuung (J.D., G.M.), Pflegewohnhaus Donaustadt Wien, Vienna, Austria.
Manuel SchabusFrom the Laboratory for Sleep, Cognition and Consciousness Research, Department of Psychology (C.B., J.L., R.d.G., M.-T.G., M. Schabus), and Centre for Cognitive Neuroscience Salzburg (CCNS) (C.B., J.L., R.d.G., M. Schabus), University of Salzburg, Austria; Surrey Sleep Research Centre (N.S.), Faculty of Health and Medical Sciences, University of Surrey, UK; Albert Schweitzer Clinic (G.P., M. Scarpatetti), Apallic Care Unit, Geriatric Health Centres of the City of Graz; and Neurologische Abteilung mit Wachkomabetreuung (J.D., G.M.), Pflegewohnhaus Donaustadt Wien, Vienna, Austria.
Albert Schweitzer Klinik · ATUniversity of Surrey · GB

Funding

Austrian Science Fund FWF W 1233Austrian Science Fund FWF Y 777
6 · The paper itself

Abstract

objectiveTo investigate the relationship between the presence of a circadian body temperature rhythm and behaviorally assessed consciousness levels in patients with disorders of consciousness (DOC; i.e., vegetative state/unresponsive wakefulness syndrome or minimally conscious state).

methodsIn a cross-sectional study, we investigated the presence of circadian temperature rhythms across 6 to 7 days using external skin temperature sensors in 18 patients with DOC. Beyond this, we examined the relationship between behaviorally assessed consciousness levels and circadian rhythmicity.

resultsAnalyses with Lomb-Scargle periodograms revealed significant circadian rhythmicity in all patients (range 23.5-26.3 hours). We found that especially scores on the arousal subscale of the Coma Recovery Scale-Revised were closely linked to the integrity of circadian variations in body temperature. Finally, we piloted whether bright light stimulation could boost circadian rhythmicity and found positive evidence in 2 out of 8 patients.

conclusionThe study provides evidence for an association between circadian body temperature rhythms and arousal as a necessary precondition for consciousness. Our findings also make a case for circadian rhythms as a target for treatment as well as the application of diagnostic and therapeutic means at times when cognitive performance is expected to peak.

Indexed as

AdolescentAdultAgedBrain InjuriesCircadian RhythmConsciousnessConsciousness DisordersCross-Sectional StudiesFemaleHumansMaleMiddle AgedPeriodicityPhototherapyPilot ProjectsSkin Temperature

Identifiers

PMID28424270
PMCPMC5444311
OpenAlexW2607404083

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LicenceCC BY
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.