Evidence map›Paper›PMID 28424248›Full record

ArticleThe Journal of experimental medicine2017

Splenic Ly6G

Justin F Deniset, Bas G Surewaard, Woo-Yong Lee, Paul Kubes

Abstract read
In one paragraph

Article in The Journal of experimental medicine, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 136 papers.

0numbers the graph read from it
0cells of the map it votes in
136citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

136 citing papers in PubMed.

  1. Isolation and identification of leukocyte populations in intracranial blood collected during mechanical thrombectomy.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2022
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76 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

4 authors.

Justin F DenisetDepartment of Physiology and Pharmacology, University of Calgary, Calgary, Alberta T2N 4N1, Canada.
Bas G SurewaardDepartment of Physiology and Pharmacology, University of Calgary, Calgary, Alberta T2N 4N1, Canada.ORCID 0000-0002-0519-1227
Woo-Yong LeeDepartment of Physiology and Pharmacology, University of Calgary, Calgary, Alberta T2N 4N1, Canada.ORCID 0000-0002-4702-8540
Paul KubesDepartment of Physiology and Pharmacology, University of Calgary, Calgary, Alberta T2N 4N1, Canada pkubes@ucalgary.ca.ORCID 0000-0002-2835-4244

Funding

CIHR
6 · The paper itself

Abstract

The spleen plays an integral protective role against encapsulated bacterial infections. Our understanding of the associated mechanisms is limited to thymus-independent (TI) antibody production by the marginal zone (MZ) B cells, leaving the contribution of other splenic compartments such as the red pulp (RP) largely unexplored despite asplenic patients succumbing to the infection in the first 24 h, suggesting important antibody-independent mechanisms. In this study, using time-lapse intravital imaging of the spleen, we identify a tropism for

Indexed as

AnimalsAntigens, LyFemaleFlow CytometryMacrophagesMaleMiceMice, Inbred C57BLNeutrophilsPneumococcal InfectionsSpleenStreptococcus pneumoniaeAntigens, LyLy6G antigen, mouse

Identifiers

PMID28424248
PMCPMC5413339

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-SA
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.