ArticleJournal of immunology (Baltimore, Md. : 1950)2017
The Histone Acetyltransferase Gcn5 Positively Regulates T Cell Activation.
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Article in Journal of immunology (Baltimore, Md. : 1950), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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0cells of the map it votes in
26citing papers in PubMed
1.9field-weighted citation impact, top 14% of its field
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
26 citing papers in PubMed, 49 citations in OpenAlex.
- Protein acylation in inflammatory diseases: from mechanisms to therapeutic strategies.Cell communication and signaling : CCS · 2025Review
- Genome-wide CRISPR screens identify critical targets to enhance CAR-NK cell antitumor potency.Cancer cell · 2025Article
- Leveraging synthetic genetic array screening to identify therapeutic targets and inhibitors for combatting azole resistance inMicrobiology spectrum · 2025Article
- PARylation of GCN5 by PARP1 mediates its recruitment to DSBs and facilitates both HR and NHEJ Repair.Cellular and molecular life sciences : CMLS · 2024Article
- Contributions of transcriptional noise to leukaemia evolution: KAT2A as a case-study.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2024Review
- TNF-α-Induced KAT2A Impedes BMMSC Quiescence by Mediating Succinylation of the Mitophagy-Related Protein VCP.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Article
- Aberrant KAT2A accumulations render TRIM22-low melanoma sensitive to Notch1 inhibitors via epigenetic reprogramming.Journal of translational medicine · 2023Article
- Regulation of insulin secretion by the post-translational modifications.Frontiers in cell and developmental biology · 2023Review
- H1.0 induces paclitaxel-resistance genes expression in ovarian cancer cells by recruiting GCN5 and androgen receptor.Cancer science · 2022Article
- KAT2A complexes ATAC and SAGA play unique roles in cell maintenance and identity in hematopoiesis and leukemia.Blood advances · 2022Article
- Review
- Germline biallelic mutation affecting the transcription factor Helios causes pleiotropic defects of immunity.Science immunology · 2021Article
- Article
- Conservation and diversity of the eukaryotic SAGA coactivator complex across kingdoms.Epigenetics & chromatin · 2021Review
- Role of Epigenetics in the Regulation of Immune Functions of the Skin.The Journal of investigative dermatology · 2021Review
- GCN5 acetyltransferase in cellular energetic and metabolic processes.Biochimica et biophysica acta. Gene regulatory mechanisms · 2021Review
- Complex functions of Gcn5 and Pcaf in development and disease.Biochimica et biophysica acta. Gene regulatory mechanisms · 2021Review
- Significant Difference of Immune Cell Fractions and Their Correlations With Differential Expression Genes in Parkinson's Disease.Frontiers in aging neuroscience · 2021Article
- Transcriptional Activation of MYC-Induced Genes by GCN5 Promotes B-cell Lymphomagenesis.Cancer research · 2020Article
- Metabolic Reprogramming in CD8Frontiers in immunology · 2020Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 6 institutions in 2 countries.
Beixue GaoDepartment of Pathology, Northwestern University Feinberg School of Medicine, Chicago, IL 60611.ORCID 0000-0002-4667-7995
Qingfei KongDepartment of Pathology, Northwestern University Feinberg School of Medicine, Chicago, IL 60611.ORCID 0000-0002-6014-7632
Yana ZhangDepartment of Pathology, Northwestern University Feinberg School of Medicine, Chicago, IL 60611.
Chawon YunDepartment of Pathology, Northwestern University Feinberg School of Medicine, Chicago, IL 60611.ORCID 0000-0002-0046-4732
Sharon Y R DentDepartment of Epigenetics and Molecular Carcinogenesis, Center for Cancer Epigenetics, University of Texas MD Anderson Cancer Center, Smithville, TX 78957.ORCID 0000-0002-4824-3269
Jianxun SongDepartment of Microbiology and Immunology, The Pennsylvania State University College of Medicine, Hershey, PA 17033.ORCID 0000-0002-9734-6176
Donna D ZhangDepartment of Pharmacology and Toxicology, College of Pharmacy, The University of Arizona, Tucson, AZ 85721.ORCID 0000-0002-8972-697X
Yiming WangDepartment of Psychiatry, Affiliated Hospital of Guizhou Medical University, Guiyang, Guizhou 550004, China; and 754603457@qq.com lixuemei8806@163.com fangd@northwestern.edu.
Xuemei LiDepartment of Neurology, Affiliated Hospital of Weifang Medical University, Weifang, Shandong Province 261053, China 754603457@qq.com lixuemei8806@163.com fangd@northwestern.edu.
Deyu FangDepartment of Pathology, Northwestern University Feinberg School of Medicine, Chicago, IL 60611; 754603457@qq.com lixuemei8806@163.com fangd@northwestern.edu.
Northwestern University · USGuiyang Medical University · CNPennsylvania State University · USThe University of Texas MD Anderson Cancer Center · USUniversity of Arizona · USWeifang Medical University · CN
Funding
NRF Transcription Factors in Environmental Stress and Disease InterventionR35ES031575 · NIEHS · UNIVERSITY OF FLORIDA · PI Donna D Zhang · 2020 to 2026
$7.1MFunctions of Mammalian Histone ModifiersR01GM067718 · NIGMS · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI DENT, SHARON Y. R. · 2003 to 2018
$3.7MThe roles of Sirt1, a deacetylase, in immune tolerance and autoimmunityR01AI079056 · NIAID · UNIVERSITY OF MISSOURI-COLUMBIA · PI FANG, DEYU · 2008 to 2017
$3.3MA novel target for type 1 diabetesDP2DK083050 · NIDDK · UNIVERSITY OF MISSOURI-COLUMBIA · PI FANG, DEYU · 2008 to 2010
$2.4MSimultaneous Targeting of IRE1a in B Cells and Macrophages for Lupus TherapyR01AR066634 · NIAMS · NORTHWESTERN UNIVERSITY AT CHICAGO · PI FANG, DEYU, ZHANG, KEZHONG · 2014 to 2018
$1.7MThe roles of Synoviolin in immune tolerance and autoimmunityR01AI108634 · NIAID · NORTHWESTERN UNIVERSITY AT CHICAGO · PI FANG, DEYU · 2014 to 2017
$1.5MThe roles of Sirt1, a deacetylase, in immune tolerance and autoimmunityR56AI079056 · NIAID · NORTHWESTERN UNIVERSITY AT CHICAGO · PI FANG, DEYU · 2012 to 2012
$386kNIAID NIH HHS R01 AI079056NIAID NIH HHS R01 AI108634NIAID NIH HHS R56 AI079056NIAMS NIH HHS R01 AR066634NIDDK NIH HHS DP2 DK083050NIEHS NIH HHS R35 ES031575NIGMS NIH HHS R01 GM067718
Abstract
Histone acetyltransferases (HATs) regulate inducible transcription in multiple cellular processes and during inflammatory and immune response. However, the functions of general control nonrepressed-protein 5 (
Indexed as
Lymphocyte ActivationAnimalsCell DifferentiationEncephalomyelitis, Autoimmune, ExperimentalGene Expression RegulationHistone AcetyltransferasesInterleukin-2MiceNFATC Transcription Factorsp300-CBP-Associated FactorPromoter Regions, GeneticProtein BindingProtein Processing, Post-TranslationalTh1 CellsTh2 CellsT-LymphocytesGCN5 histone acetyltransferase, mouseHistone AcetyltransferasesInterleukin-2NFATC Transcription Factorsp300-CBP-Associated Factor
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.