ArticleClinical cancer research : an official journal of the American Association for Cancer Research2017
Global Protease Activity Profiling Provides Differential Diagnosis of Pancreatic Cysts.
Open access · greenAbstract read
In one paragraph
Article in Clinical cancer research : an official journal of the American Association for Cancer Research, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed, 1 pooled it
2.4field-weighted citation impact, top 10% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
29 citing papers in PubMed, 1 synthesis or guideline pooled it, 47 citations in OpenAlex.
- Biochemical Intracystic Biomarkers in the Differential Diagnosis of Pancreatic Cystic Lesions.Medicina (Kaunas, Lithuania) · 2022Pooled it
- Mass Spectrometry-Based Comprehensive Analysis of Pancreatic Cyst Fluids.BioMed research international · 2018Trial
- The Lysosome-Cathepsin Axis in Pancreatic Cancer: Mechanisms of Stromal Remodeling, Immune Evasion, and Therapy Resistance.Biomolecules · 2026Review
- Proteolysis activity mapping and substrate discovery platform for identifying tumor-activated biosensors.Nature chemical biology · 2026Article
- mspms: an R package and GUI for multiplex substrate profiling by mass spectrometry.BMC bioinformatics · 2026Article
- Identifying protease-activated targets and exploring therapeutic applications.Expert opinion on therapeutic targets · 2025Review
- Use of protease substrate specificity screening in the rational design of selective protease inhibitors with unnatural amino acids: Application to HGFA, matriptase, and hepsin.Protein science : a publication of the Protein Society · 2024Article
- Addressing the unmet clinical need for low-volume assays in early diagnosis of pancreatic cancer.Frontiers in gastroenterology (Lausanne, Switzerland) · 2023Article
- Multiplex substrate profiling by mass spectrometry for proteases.Methods in enzymology · 2023Article
- Article
- Translation of a Protease Turnover Assay for Clinical Discrimination of Mucinous Pancreatic Cysts.Diagnostics (Basel, Switzerland) · 2022Article
- In Vivo Measurement of Granzyme Proteolysis from Activated Immune Cells with PET.ACS central science · 2021Article
- A novel class of TMPRSS2 inhibitors potently block SARS-CoV-2 and MERS-CoV viral entry and protect human epithelial lung cells.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- Differential Neuropeptidomes of Dense Core Secretory Vesicles (DCSV) Produced at Intravesicular and Extracellular pH Conditions by Proteolytic Processing.ACS chemical neuroscience · 2021Article
- Global Protease Activity Profiling Identifies HER2-Driven Proteolysis in Breast Cancer.ACS chemical biology · 2021Article
- Activatable Zymography Probes EnableCancer research · 2021Article
- High-Resolution Mass Spectrometry-Based Approaches for the Detection and Quantification of Peptidase Activity in Plasma.Molecules (Basel, Switzerland) · 2020Article
- Article
- Giant magnetoresistive biosensors for real-time quantitative detection of protease activity.Scientific reports · 2020Article
- Molecular Diagnosis of Cystic Neoplasms of the Pancreas: a Review.Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract · 2020Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
14 authors at 5 institutions in 1 country.
Sam L IvryDepartment of Pharmaceutical Chemistry, University of California, San Francisco, San Francisco, California.
Jeremy M SharibDepartment of Surgery, University of California, San Francisco, San Francisco, California.
Dana A DominguezDepartment of Surgery, University of California, San Francisco, San Francisco, California.
Nilotpal RoyDiabetes Center, Department of Medicine, University of California, San Francisco, San Francisco, California.
Stacy E HatcherDepartment of Surgery, University of California, San Francisco, San Francisco, California.
Michele T Yip-SchneiderDepartment of Surgery, Indiana University School of Medicine, Indianapolis, Indiana.
C Max SchmidtDepartment of Surgery, Indiana University School of Medicine, Indianapolis, Indiana.
Randall E BrandDivision of Gastroenterology, Hepatology, and Nutrition, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania.
Walter G ParkDepartment of Medicine, Stanford University School of Medicine, Stanford, California.
Matthias HebrokDiabetes Center, Department of Medicine, University of California, San Francisco, San Francisco, California.
Grace E KimDepartment of Pathology, University of California, San Francisco, San Francisco, California.
Anthony J O'DonoghueSkaggs School of Pharmacy and Pharmaceutical Chemistry, University of California, San Diego, La Jolla, California.
Kimberly S KirkwoodDepartment of Surgery, University of California, San Francisco, San Francisco, California.
Charles S CraikDepartment of Pharmaceutical Chemistry, University of California, San Francisco, San Francisco, California. Charles.Craik@ucsf.edu.
University of California, San Francisco · USIndiana University – Purdue University Indianapolis · USStanford Medicine · USUniversity of California San Diego · USUniversity of Pittsburgh Medical Center · US
Funding
Translational InformaticsP30CA082103 · NCI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Kate Taylor Shumate · 1999 to 2026
$209.7MEngaging University of California Stakeholders for Biorespository ResearchUL1TR000004 · NCATS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI GRANDIS, JENNIFER RUBIN · 2012 to 2015
$78.0MUC BRAID Center for Accelerated Innovation COVID-19 diagnostic project developmentU54HL119893 · NHLBI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI PALAZZOLO, MICHAEL J · 2013 to 2020
$18.3MUCSF/UCB Joint Graduate Group in BIoengineeringT32GM008155 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI DESAI, TEJAL A. · 1985 to 2020
$12.2MPHARMACEUTICAL SCIENCES AND PHARMACOGENOMICST32GM007175 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI AHITUV, NADAV, KROETZ, DEANNA L · 1985 to 2021
$7.1MRenewable antibodies to secreted proteins and single and multi-pass cell surfaceP41CA196276 · NCI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI MARKS, JAMES D. · 2014 to 2018
$5.8MImaging and Molecular Correlates of Progression in Cystic Neoplasms of the PancreasU01CA196403 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI MAITRA, ANIRBAN · 2015 to 2020
$5.8MDetection of Pre-Invasive Pancreatic Cysts Using Protein and Glycan BiomarkersU01CA152653 · NCI · VAN ANDEL RESEARCH INSTITUTE · PI ALLEN, PETER J, BRAND, RANDALL · 2010 to 2021
$5.8MEmbryonic Signaling Pathways in Pancreatic CancerR01CA112537 · NCI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI HEBROK, MATTHIAS · 2004 to 2014
$2.7MEpigenetic regulation of pancreatic cancerR01CA172045 · NCI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI HEBROK, MATTHIAS · 2014 to 2018
$1.6MNon-invasive Differentiation of Benign Lesions from Aggressive Pancreatic CancerR21CA185689 · NCI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI CRAIK, CHARLES SCOTT, KIRKWOOD, KIMBERLY SAUNDERS · 2015 to 2016
$379kNCATS NIH HHS UL1 TR000004NCI NIH HHS P30 CA082103NCI NIH HHS P41 CA196276NCI NIH HHS R01 CA112537NCI NIH HHS R01 CA172045NCI NIH HHS R21 CA185689NCI NIH HHS U01 CA152653NCI NIH HHS U01 CA196403NHLBI NIH HHS U54 HL119893NIGMS NIH HHS T32 GM007175NIGMS NIH HHS T32 GM008155
Abstract
PubMed holds no abstract for this paper.
Indexed as
AnimalsBiomarkers, TumorCarcinoembryonic AntigenCathepsin ECyst FluidDiagnosis, DifferentialFluorescent DyesHumansMice, KnockoutMice, TransgenicNeoplasms, Cystic, Mucinous, and SerousPancreatic CystPancreatic NeoplasmsPancreatic PseudocystPepsin APeptide HydrolasesBiomarkers, TumorCarcinoembryonic AntigenCathepsin EFluorescent DyesgastricsinPepsin APeptide Hydrolases
Identifiers
What OpenQuestion holds
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Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.