ArticleBlood2017
Hypoxic adaptation of leukemic cells infiltrating the CNS affords a therapeutic strategy targeting VEGFA.
Abstract readLetter
In one paragraph
Article in Blood, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed, 1 pooled it
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Mass spectrometry-based proteomics of cerebrospinal fluid in pediatric central nervous system malignancies: a systematic review with meta-analysis of individual patient data.Fluids and barriers of the CNS · 2024Pooled it
- Central nervous system involvement in acute lymphoblastic leukemia: pathogenesis and targeted therapy.Leukemia · 2026Review
- Cerebrospinal fluid attenuates the efficacy of methotrexate against acute lymphoblastic leukemia cells.Blood neoplasia · 2025Article
- Dynamic evolution of TCF3-PBX1 leukemias at the single-cell level under chemotherapy pressure.HemaSphere · 2025Article
- A brain organoid/ALL coculture model reveals the AP-1 pathway as critically associated with CNS involvement of BCP-ALL.Blood advances · 2024Article
- Integrins and the Metastasis-like Dissemination of Acute Lymphoblastic Leukemia to the Central Nervous System.Cancers · 2023Review
- Review
- The role of microenvironment in the initiation and evolution of B-cell precursor acute lymphoblastic leukemia.Frontiers in oncology · 2023Review
- Central nervous system involvement in childhood acute lymphoblastic leukemia: challenges and solutions.Leukemia · 2022Review
- Targeting Leukemia-Initiating Cells and Leukemic Niches: The Next Therapy Station for T-Cell Acute Lymphoblastic Leukemia?Cancers · 2022Review
- The first Japanese biobank of patient-derived pediatric acute lymphoblastic leukemia xenograft models.Cancer science · 2022Article
- High BMP4 expression in low/intermediate risk BCP-ALL identifies children with poor outcomes.Blood · 2022Article
- Co-Detection of VEGF-A and Its Regulator, microRNA-181a, May Indicate Central Nervous System Involvement in Pediatric Leukemia.Pathology oncology research : POR · 2022Article
- Multiomic Profiling of Central Nervous System Leukemia Identifies mRNA Translation as a Therapeutic Target.Blood cancer discovery · 2022Article
- A narrative review of central nervous system involvement in acute leukemias.Annals of translational medicine · 2021Review
- Metabolic Reprogramming and Cell Adhesion in Acute Leukemia Adaptation to the CNS Niche.Frontiers in cell and developmental biology · 2021Review
- Direct Delivery ofMolecular therapy oncolytics · 2020Article
- When the bond breaks - targeting adhesion of leukemia cells to the meninges.Haematologica · 2020Article
- MicroRNA-181a as novel liquid biopsy marker of central nervous system involvement in pediatric acute lymphoblastic leukemia.Journal of translational medicine · 2020Article
- Involvement of the central nervous system in acute lymphoblastic leukemia: opinions on molecular mechanisms and clinical implications based on recent data.Cancer metastasis reviews · 2020Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
27 authors.
Itaru KatoCancer Institute, University College London, London, United Kingdom.ORCID 0000-0002-2932-4960
Yoko NishinakaDepartment of Clinical Application, Center for iPS Cell Research and Application.
Masahiro NakamuraDepartment of Life Science Frontiers, Center for iPS Cell Research and Application, Kyoto University, Kyoto, Japan.
Ayse U AkarcaDepartment of Cellular Pathology, University College London, London, United Kingdom.
Akira NiwaDepartment of Clinical Application, Center for iPS Cell Research and Application.
Hiroki OzawaCancer Institute, University College London, London, United Kingdom.
Kenichi YoshidaDepartment of Pathology and Tumor Biology, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
Makiko MoriDepartment of Hematology/Oncology, Saitama Children's Medical Center, Saitama, Japan.
Dapeng WangCancer Institute, University College London, London, United Kingdom.
Makiko MoritaHuman Health Sciences, Kyoto University, Kyoto, Japan.
Hiroo UenoDepartment of Pediatrics, and.
Yusuke ShiozawaDepartment of Pediatrics.
Yuichi ShiraishiLaboratory of DNA Information Analysis, Human Genome Center, Institute of Medical Science, and.
Satoru MiyanoLaboratory of DNA Information Analysis, Human Genome Center, Institute of Medical Science, and.
Rajeev GuptaCancer Institute, University College London, London, United Kingdom.
Katsutsugu UmedaDepartment of Pediatrics, and.
Kenichiro WatanabeDepartment of Pediatrics, and.
Katsuyoshi KohDepartment of Hematology/Oncology, Saitama Children's Medical Center, Saitama, Japan.
Souichi AdachiHuman Health Sciences, Kyoto University, Kyoto, Japan.
Toshio HeikeDepartment of Pediatrics, and.
Megumu K SaitoDepartment of Clinical Application, Center for iPS Cell Research and Application.ORCID 0000-0001-8813-3614
Masashi SanadaDepartment of Advanced Diagnosis, Clinical Research Center, Nagoya Medical Center, Aichi, Japan.
Seishi OgawaDepartment of Pathology and Tumor Biology, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
Teresa MarafiotiDepartment of Cellular Pathology, University College London, London, United Kingdom.
Akira WatanabeDepartment of Life Science Frontiers, Center for iPS Cell Research and Application, Kyoto University, Kyoto, Japan.
Tatsutoshi NakahataDepartment of Clinical Application, Center for iPS Cell Research and Application.
Tariq EnverCancer Institute, University College London, London, United Kingdom.
Funding
Cancer Research UK 12796Cancer Research UK 13100Medical Research Council MR/M009033/1Medical Research Council MR/N000838/1
Abstract
PubMed holds no abstract for this paper.
Indexed as
Central Nervous System NeoplasmsPrecursor B-Cell Lymphoblastic Leukemia-LymphomaAnimalsCell HypoxiaHumansMiceVascular Endothelial Growth Factor AXenograft Model Antitumor AssaysVascular Endothelial Growth Factor AVEGFA protein, human
Identifiers
What OpenQuestion holds
Textmetadata
Read underepoch 390
Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.