ArticleBMC medicine2017
Antidepressant use and cognitive decline in community-dwelling elderly people - The Three-City Cohort.
Article in BMC medicine, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
11 citing papers in PubMed, 1 synthesis or guideline pooled it, 21 citations in OpenAlex.
- The effects of selective serotonin reuptake inhibitors on memory functioning in older adults: A systematic literature review.Journal of psychopharmacology (Oxford, England) · 2022Pooled it
- Review
- Antidepressant use and cognitive decline in patients with dementia: a national cohort study.BMC medicine · 2025Article
- Different risk and protective factors predict change of planning ability in middle versus older age.Scientific reports · 2024Article
- History of Psychoactive Medication a Risk Factor for Neurocognitive Decline After Cardiac Surgery.The Journal of surgical research · 2024Article
- Selective serotonin reuptake inhibitor use, age-related neuropathology and cognition in late-life.Psychiatry research · 2023Article
- Geriatric Depression and Cognitive Impairment-An Update.Indian journal of psychological medicine · 2021Review
- Estimating associations between antidepressant use and incident mild cognitive impairment in older adults with depression.PloS one · 2020Article
- Latent Classes of Cognitive Functioning Among Depressed Older Adults Without Dementia.Journal of the International Neuropsychological Society : JINS · 2019Article
- Antidepressant Use and Cognitive Outcomes in Very Old Women.The journals of gerontology. Series A, Biological sciences and medical sciences · 2018Article
- Depressive disorders in the elderly and dementia: An update.Dementia & neuropsychologiaArticle
Corrections and comments
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Authors and funding
10 authors at 6 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundCognitive impairment is very common in late-life depression, principally affecting executive skills and information processing speed. The aim of the study was to examine the effect of antidepressant treatment on cognitive performances over a 10-year period.
methodsThe community-based cohort included 7381 participants aged 65 years and above. Five cognitive domains (verbal fluency, psychomotor speed, executive function, visuospatial skills and global cognition) were assessed up to five times over 10 years of follow-up. Treatment groups included participants under a specific antidepressant class at both baseline and the first follow-up and their follow-up cognitive data were considered until the last consecutive follow-up with a report of antidepressant use of the same class. Linear mixed models were used to compare baseline cognitive performance and cognitive decline over time according to antidepressant treatment. The models were adjusted for multiple confounders including residual depressive symptoms assessed by the Center for Epidemiologic Studies-Depression scale.
resultsAt baseline, 4.0% of participants were taking antidepressants. Compared to non-users, tricyclic antidepressant users had lower baseline performances in verbal fluency, visual memory and psychomotor speed, and selective serotonin reuptake inhibitor users in verbal fluency and psychomotor speed. For the two other cognitive abilities, executive function and global cognition, no significant differences were found at baseline irrespective of the antidepressant class. Regarding changes over time, no significant differences were observed in comparison with non-users whatever the cognitive domain, except for a slight additional improvement over the follow-up in verbal fluency skills for tricyclic antidepressant users.
conclusionsIn this large elderly general population cohort, we found no evidence for an association between antidepressant use and post-treatment cognitive decline over 10 years of follow-up in various cognitive domains.
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