ArticleGenetics, selection, evolution : GSE2017
Use of multi-trait and random regression models to identify genetic variation in tolerance to porcine reproductive and respiratory syndrome virus.
Article in Genetics, selection, evolution : GSE, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed.
- PRRSV-2 variant classification: a dynamic nomenclature for enhanced monitoring and surveillance.mSphere · 2025Article
- Importance and variability of the paternal component in sow reproductive traits.Journal of applied genetics · 2024Review
- The WUR0000125 PRRS resilience SNP had no apparent effect on pigs' infectivity and susceptibility in a novel transmission trial.Genetics, selection, evolution : GSE · 2023Article
- Change of Gut Microbiota in PRRSV-Resistant Pigs and PRRSV-Susceptible Pigs from Tongcheng Pigs and Large White Pigs Crossed Population upon PRRSV Infection.Animals : an open access journal from MDPI · 2022Article
- Genomic study of the resilience of buffalo cows to a negative energy balance.Journal of applied genetics · 2022Article
- Breeding for disease resilience: opportunities to manage polymicrobial challenge and improve commercial performance in the pig industry.CABI agriculture and bioscience · 2022Review
- Why breed disease-resilient livestock, and how?Genetics, selection, evolution : GSE · 2020Review
- Selection for Favorable Health Traits: A Potential Approach to Cope with Diseases in Farm Animals.Animals : an open access journal from MDPI · 2020Review
- Genetic differences in host infectivity affect disease spread and survival in epidemics.Scientific reports · 2019Article
- Disentangling Genetic Variation for Resistance and Endurance to Scuticociliatosis in Turbot Using Pedigree and Genomic Information.Frontiers in genetics · 2019Article
- Phenotypic and genetic variation in the response of chickens to Eimeria tenella induced coccidiosis.Genetics, selection, evolution : GSE · 2018Article
- Harnessing longitudinal information to identify genetic variation in tolerance of pigs to Porcine Reproductive and Respiratory Syndrome virus infection.Genetics, selection, evolution : GSE · 2018Article
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Authors and funding
12 authors.
Funding
Abstract
backgroundA host can adopt two response strategies to infection: resistance (reduce pathogen load) and tolerance (minimize impact of infection on performance). Both strategies may be under genetic control and could thus be targeted for genetic improvement. Although there is evidence that supports a genetic basis for resistance to porcine reproductive and respiratory syndrome (PRRS), it is not known whether pigs also differ genetically in tolerance. We determined to what extent pigs that have been shown to vary genetically in resistance to PRRS also exhibit genetic variation in tolerance. Multi-trait linear mixed models and random regression sire models were fitted to PRRS Host Genetics Consortium data from 1320 weaned pigs (offspring of 54 sires) that were experimentally infected with a virulent strain of PRRS virus to obtain genetic parameter estimates for resistance and tolerance. Resistance was defined as the inverse of within-host viral load (VL) from 0 to 21 (VL
resultsMulti-trait analysis of ADG associated with either low or high VL was not indicative of genetic variation in tolerance. Similarly, random regression models for ADG
conclusionsEvidence for genetic variation in tolerance of pigs to PRRS was weak when based on data from infected piglets only. However, simulations indicated that genetic variance in tolerance may exist and could be detected if comparable data on uninfected relatives were available. In conclusion, of the two defense strategies, genetics of tolerance is more difficult to elucidate than genetics of resistance.
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