Evidence map›Paper›PMID 28424049›Full record

ArticleBMC gastroenterology2017

Findings in young adults at colonoscopy from a hospital service database audit.

Stephanie Wong, Ilmars Lidums, Christophe Rosty, Andrew Ruszkiewicz, Susan Parry, Aung Ko Win, Yoko Tomita, Sina Vatandoust, Amanda Townsend, Dainik Patel and 12 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC gastroenterology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed, 1 pooled it
1.4field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 1 synthesis or guideline pooled it, 26 citations in OpenAlex.

  1. Pooled it
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  8. Advances in Management of Brain and Leptomeningeal Metastases.Current neurology and neuroscience reports · 2020
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

22 authors at 9 institutions in 2 countries.

Stephanie WongDepartment of Gastroenterology, The Queen Elizabeth Hospital, Woodville South 5011, Adelaide, South Australia, Australia.
Ilmars LidumsDepartment of Gastroenterology, The Queen Elizabeth Hospital, Woodville South 5011, Adelaide, South Australia, Australia.
Christophe RostyEnvoi Specialist Pathologists, Kelvin Grove 4059, Brisbane, QLD, Australia.
Andrew RuszkiewiczDivision of Anatomical Pathology, SA Pathology, Adelaide, 5000, South Australia, Australia.
Susan ParryFamilial GI Cancer Service and Ministry of Health Bowel Cancer Programme, Auckland City Hospital, Auckland, New Zealand.
Aung Ko WinCentre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Parkville 3010, Melbourne, VIC, Australia.
Yoko TomitaDepartment of Haematology and Oncology, The Queen Elizabeth Hospital, Woodville South 5011, Adelaide, South Australia, Australia.
Sina VatandoustFlinders Medical Centre, Bedford Park 5042, Adelaide, South Australia, Australia.
Amanda TownsendDepartment of Haematology and Oncology, The Queen Elizabeth Hospital, Woodville South 5011, Adelaide, South Australia, Australia.
Dainik PatelFlinders Medical Centre, Bedford Park 5042, Adelaide, South Australia, Australia.
Jennifer E HardinghamDepartment of Haematology and Oncology, The Queen Elizabeth Hospital, Woodville South 5011, Adelaide, South Australia, Australia.
David RoderCancer Epidemiology and Population Health, University of South Australia, Adelaide, 5000, South Australia, Australia.
Eric SmithDepartment of Haematology and Oncology, The Queen Elizabeth Hospital, Woodville South 5011, Adelaide, South Australia, Australia.
Paul DrewSchool of Nursing and Midwifery, Flinders University, Bedford Park 5042, Adelaide, South Australia, Australia.
Julie MarkerCancer Voices SA, Kensington Park 5068, Adelaide, South Australia, Australia.
Wendy UylakiDepartment of Gastroenterology, The Queen Elizabeth Hospital, Woodville South 5011, Adelaide, South Australia, Australia.
Peter HewettUniversity of Adelaide Department of Surgery, The Queen Elizabeth Hospital, Woodville South 5011, Adelaide, South Australia, Australia.
Daniel L WorthleySchool of Medicine, University of Adelaide, Adelaide, 5000, South Australia, Australia.
Erin SymondsFlinders Centre for Innovation in Cancer, Flinders University, Bedford Park 5042, Adelaide, South Australia, Australia.
Graeme P YoungFlinders Centre for Innovation in Cancer, Flinders University, Bedford Park 5042, Adelaide, South Australia, Australia.
Timothy J PriceDepartment of Haematology and Oncology, The Queen Elizabeth Hospital, Woodville South 5011, Adelaide, South Australia, Australia.
Joanne P YoungDepartment of Haematology and Oncology, The Queen Elizabeth Hospital, Woodville South 5011, Adelaide, South Australia, Australia. joanne.young@adelaide.edu.au.
Queen Elizabeth Hospital · AUFlinders University · AUThe University of Adelaide · AUFlinders Medical Centre · AUCentre for Cancer Biology · AUMinistry of Health · NZThe University of Melbourne · AUThe University of Queensland · AUUniversity of South Australia · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundColorectal cancer (CRC) diagnosed at <50 years is predominantly located in the distal colon and rectum. Little is known about which lesion subtypes may serve as CRC precursors in young adults. The aim of this work was to document the prevalence and histological subtype of lesions seen in patients aged <50 years, and any associated clinical features.

methodsAn audit of the colonoscopy database at The Queen Elizabeth Hospital in Adelaide, South Australia over a 12-month period was undertaken. Findings were recorded from both colonoscopy reports and corresponding histological examination of excised lesions.

resultsData were extracted from colonoscopies in 2064 patients. Those aged <50 comprised 485 (24%) of the total. CRC precursor lesions (including sessile serrated adenoma/polyps (SSA/P), traditional serrated adenomas, tubular adenomas ≥10 mm or with high-grade dysplasia, and conventional adenomas with villous histology) were seen in 4.3% of patients aged <50 and 12.9% of patients aged ≥50 (P <0.001). Among colonoscopies yielding CRC precursor lesions in patients under 50 years, SSA/P occurred in 52% of procedures (11/21), compared with 27% (55/204) of procedures in patients aged 50 and older (P = 0.02). SSA/P were proximally located in (10/11) 90% of patients aged under 50, and 80% (43/54) of those aged 50 and older (P = 0.46).

conclusionsSSA/P were the most frequently observed CRC precursor lesions in patients aged <50. Most CRCs in this age group are known to arise in the distal colon and rectum suggesting that lesions other than SSA/P may serve as the precursor for the majority of early-onset CRC.

Indexed as

ColonoscopyAdenomaAdolescentAdultAgedAged, 80 and overColonColonic PolypsColorectal NeoplasmsCross-Sectional StudiesDatabases, FactualFemaleGastrointestinal HemorrhageHospitals, TeachingHumansHyperplasiaAdenomaEarly-onset colorectal cancerSessile serrated adenoma

Identifiers

PMID28424049
PMCPMC5395776
OpenAlexW2605741540

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.