Evidence map›Paper›PMID 28423874›Full record

ArticleAsian-Australasian journal of animal sciences2017

The relationship between the variants in the 5'-untranslated regions of equine chorionic gonadotropin genes and serum equine chorionic gonadotropin levels.

ShuQin Liu, Song Lian, YunZhou Yang, ChunZheng Fu, HongYing Ma, ZhiYao Xiong, Yao Ling, ChunJiang Zhao

Open access · goldAbstract read
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In one paragraph

Article in Asian-Australasian journal of animal sciences, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
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0citing papers in PubMed
–field-weighted citation impact, top 84% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

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5 · Who and what money

Authors and funding

8 authors at 1 institution in 2 countries.

ShuQin LiuEquine Center, China Agricultural University, Beijing 100193, China.
Song LianCollege of Animal Science and Technology, China Agricultural University, Beijing 100193, China.
YunZhou YangEquine Center, China Agricultural University, Beijing 100193, China.
ChunZheng FuEquine Center, China Agricultural University, Beijing 100193, China.
HongYing MaEquine Center, China Agricultural University, Beijing 100193, China.
ZhiYao XiongEquine Center, China Agricultural University, Beijing 100193, China.
Yao LingCollege of Animal Science and Technology, China Agricultural University, Beijing 100193, China.
ChunJiang ZhaoEquine Center, China Agricultural University, Beijing 100193, China.
China Agricultural University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveAn experiment was conducted to study the association between the single nucleotide polymorphisms (SNPs) in 5'-untranslated regions (5'-UTR) of equine chorionic gonadotropin (eCG) genes and the serum eCG levels.

methodsSNPs in 5'-UTR of eCG genes were screened across 10 horse breeds, including 7 Chinese indigenous breeds and 3 imported breeds using iPLEX chemistry, and the association between the serum eCG levels of 174 pregnant Da'an mares and their serum eCG levels (determined with ELISA) was analyzed.

resultsFour SNPs were identified in the 5'-UTR of the eCGα gene, and one of them was unique in the indigenous breeds. There were 2 SNPs detected at the 5' end of the eCGβ subunit gene, and one of them was only found in the Chinese breeds. The SNP g.39948246T>C at the 5'-UTR of eCGα was associated significantly with eCG levels of 75-day pregnant mare serum (p<0.05) in Da'an mares. Prediction analysis on binding sites of transcription factors showed that the g.39948246T>C mutation causes appearance of the specific binding site of hepatocyte nuclear factor 3 forkhead homolog 2 (HFH-2), which is a transcriptional repressor belonging to the forkhead protein family of transcription factors.

conclusionThe SNP g.39948246T>C at the 5'-UTR of eCGα is associated with eCG levels of 75-day pregnant mare serum (p<0.05).

Indexed as

Equine Chorionic Gonadotropin (eCG)Single Nucleotide Polymorphism (SNP)Transcription Factor

Identifiers

PMID28423874
PMCPMC5666169
OpenAlexW2766087181

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