ArticleOncotarget2017
Correlations between intravoxel incoherent motion (IVIM) parameters and histological findings in rectal cancer: preliminary results.
Article in Oncotarget, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers, 2 of them syntheses that pooled it.
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Who cites it
36 citing papers in PubMed, 2 syntheses or guidelines pooled it, 55 citations in OpenAlex.
- Pretreatment Apparent Diffusion Coefficient Cannot Predict Histopathological Features and Response to Neoadjuvant Radiochemotherapy in Rectal Cancer: A Meta-Analysis.Digestive diseases (Basel, Switzerland) · 2022Pooled it
- An evidence-based approach to assess the accuracy of intravoxel incoherent motion imaging for the grading of brain tumors.Medicine · 2018Pooled it
- Diffusion-weighted imaging in rectal cancer MRI from theory to practice.Abdominal radiology (New York) · 2026Review
- Clinical utility and reproducibility of intravoxel incoherent motion MRI in rectal cancer: a structured narrative review.Frontiers in medicine · 2026Review
- Pretreatment intravoxel incoherent motion histogram metrics and clinical characteristics for prediction of perineural invasion status and survival in patients with rectal cancer.Insights into imaging · 2025Article
- Combination of intravoxel incoherent motion histogram parameters and clinical characteristics for predicting response to neoadjuvant chemoradiation in patients with locally advanced rectal cancer.Abdominal radiology (New York) · 2025Article
- Dynamic contrast‑enhanced MRI combined with intravoxel incoherent motion in quantitative evaluation for preoperative risk stratification of resectable rectal adenocarcinoma.Oncology letters · 2025Article
- Diagnostic Efficacy and Correlation of Intravoxel Incoherent Motion (IVIM) and Contrast-Enhanced (CE) MRI Perfusion Parameters in Oncology Imaging: A Systematic Review and Meta-Analysis.International journal of biomedical imaging · 2025Review
- The Role of Predictive and Prognostic MRI-Based Biomarkers in the Era of Total Neoadjuvant Treatment in Rectal Cancer.Cancers · 2024Review
- Histogram analysis based on intravoxel incoherent motion diffusion-weighted imaging for determining the perineural invasion status of rectal cancer.Quantitative imaging in medicine and surgery · 2024Article
- Precise Prostate Cancer Assessment Using IVIM-Based Parametric Estimation of Blood Diffusion from DW-MRI.Bioengineering (Basel, Switzerland) · 2024Article
- A nomogram based on MRI radiomics features of mesorectal fat for diagnosing T2- and T3-stage rectal cancer.Abdominal radiology (New York) · 2024Article
- Higher perfusion of rectum carcinoma relative to tumor-free rectal wall: quantification by a new imaging biomarker diffusion-derived vessel density (DDVD).Quantitative imaging in medicine and surgery · 2024Article
- Preoperative Grading of Rectal Cancer with Multiple DWI Models, DWI-Derived Biological Markers, and Machine Learning Classifiers.Bioengineering (Basel, Switzerland) · 2023Article
- A correlative study between IVIM-DWI parameters and VEGF and MMPs expression in hepatocellular carcinoma.Quantitative imaging in medicine and surgery · 2023Article
- Lymph Nodes Evaluation in Rectal Cancer: Where Do We Stand and Future Perspective.Journal of clinical medicine · 2022Review
- Application of dual-layer spectral detector computed tomography to evaluate the expression of Ki-67 in colorectal cancer.Journal of the Chinese Medical Association : JCMA · 2022Article
- Investigation of breast cancer microstructure and microvasculature from time-dependent DWI and CEST in correlation with histological biomarkers.Scientific reports · 2022Article
- The Value of Intravoxel Incoherent Motion Diffusion-Weighted Magnetic Resonance Imaging Combined With Texture Analysis of Evaluating the Extramural Vascular Invasion in Rectal Adenocarcinoma.Frontiers in oncology · 2022Article
- Combining Clinicopathology, IVIM-DWI and Texture Parameters for a Nomogram to Predict Treatment Response to Neoadjuvant Chemoradiotherapy in Locally Advanced Rectal Cancer Patients.Frontiers in oncology · 2022Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Our purpose was to correlate different intravoxel incoherent motion (IVIM), histopathological and clinical parameters in rectal cancer. 17 patients with histologically proven rectal cancer investigated on a 3.T device were included into the study. DWI was performed using a multi-slice single-shot echo-planar imaging sequence with b values of 0, 50, 200, 500 and 1000 s/mm.2 A polygonal region of interest was drawn within the tumors on every b image. The following parameters were retrieved from IVIM: apparent diffusion coefficient (ADC), true diffusion (D), pseudo diffusion coefficient (D*), perfusion factor (f), and relative perfusion f·D*. In every case, cell count, nucleic areas, proliferation index KI 67, and microvessel density were estimated on histopathological specimens. Pearson's correlation coefficient was used to analyze the association between the parameters. ADC correlated well with KI 67 index and D tended to correlate with cell count and KI 67. ADC and D tended to correlate with total nucleic area. The perfusion factor f correlated well with stained vessel area, total vessel area, and vessel count. D* and fD* correlated with mean vessel diameter. Distant metastasized tumors had higher D* and fD* values. IVIM parameter reflected different clinical and histopathological features in rectal cancer.
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