Evidence map›Paper›PMID 28423320›Full record

ArticleCell reports2017

Sequence and Structural Analyses Reveal Distinct and Highly Diverse Human CD8

Guobing Chen, Xinbo Yang, Annette Ko, Xiaoping Sun, Mingming Gao, Yongqing Zhang, Alvin Shi, Roy A Mariuzza, Nan-Ping Weng

Abstract read
In one paragraph

Article in Cell reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 97 papers.

0numbers the graph read from it
0cells of the map it votes in
97citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

97 citing papers in PubMed.

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  14. General and individualized changes in T cell immunity during aging.Journal of immunology (Baltimore, Md. : 1950) · 2025
    Review
  15. Review
  16. Article
  17. Review
  18. Article
  19. Article
  20. Article

37 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Guobing ChenLaboratory of Molecular Biology and Immunology, National Institute on Aging, NIH, Baltimore, MD 21224, USA.
Xinbo YangW.M. Keck Laboratory for Structural Biology, University of Maryland Institute for Bioscience and Biotechnology Research, Rockville, MD 20850, USA; Department of Cell Biology and Molecular Genetics, University of Maryland, College Park, MD 20742, USA.
Annette KoLaboratory of Molecular Biology and Immunology, National Institute on Aging, NIH, Baltimore, MD 21224, USA.
Xiaoping SunLaboratory of Molecular Biology and Immunology, National Institute on Aging, NIH, Baltimore, MD 21224, USA.
Mingming GaoW.M. Keck Laboratory for Structural Biology, University of Maryland Institute for Bioscience and Biotechnology Research, Rockville, MD 20850, USA; Department of Cell Biology and Molecular Genetics, University of Maryland, College Park, MD 20742, USA.
Yongqing ZhangLaboratory of Genetics, National Institute on Aging, NIH, Baltimore, MD 21224, USA.
Alvin ShiLaboratory of Molecular Biology and Immunology, National Institute on Aging, NIH, Baltimore, MD 21224, USA.
Roy A MariuzzaW.M. Keck Laboratory for Structural Biology, University of Maryland Institute for Bioscience and Biotechnology Research, Rockville, MD 20850, USA; Department of Cell Biology and Molecular Genetics, University of Maryland, College Park, MD 20742, USA.
Nan-Ping WengLaboratory of Molecular Biology and Immunology, National Institute on Aging, NIH, Baltimore, MD 21224, USA. Electronic address: wengn@mail.nih.gov.

Funding

Mechanisms Of Transcriptional Regulation in Memory lymphocyte Response and AgingZIAAG000757 · NIA · NATIONAL INSTITUTE ON AGING · PI WENG, NAN-PING PETER · 2009 to 2025
$7.9M
TCR repertoire: size, diversity, and functionZIAAG000499 · NIA · NATIONAL INSTITUTE ON AGING · PI WENG, NAN-PING PETER · 2017 to 2025
$3.6M
STRUCTURE AND FUNCTION OF T CELL ANTIGEN RECEPTORSR37AI036900 · NIAID · UNIVERSITY OF MD BIOTECHNOLOGY INSTITUTE · PI MARIUZZA, ROY A · 2000 to 2009
$3.2M
STRUCTURE AND FUNCTION OF T CELL ANTIGEN RECEPTORSR01AI036900 · NIAID · UNIV OF MARYLAND, COLLEGE PARK · PI MARIUZZA, ROY A · 1995 to 2014
$1.8M
Intramural NIH HHS ZIA AG000757NIAID NIH HHS HHSN272201300006CNIAID NIH HHS R01 AI036900NIAID NIH HHS R37 AI036900
6 · The paper itself

Abstract

A diverse T cell receptor (TCR) repertoire is essential for controlling viral infections. However, information about TCR repertoires to defined viral antigens is limited. We performed a comprehensive analysis of CD8

Indexed as

AdultAmino Acid MotifsAmino Acid SequenceAntibody AffinityAntigens, ViralCD8-Positive T-LymphocytesClone CellsComplementarity Determining RegionsConsensus SequenceCytomegalovirusHLA-A2 AntigenHumansImmunodominant EpitopesInfluenza A virusPeptidesProtein BindingAntigens, ViralComplementarity Determining RegionsHLA-A2 AntigenImmunodominant EpitopesPeptidesReceptors, Antigen, T-CellCD8 T cellshumanTCR-pMHC structureTCR repertoireαβ TCRs for CMV-NLVαβ TCRs for IAV-GIL

Identifiers

PMID28423320
PMCPMC5472051

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.