ArticleCell reports2017
Loss of Navβ4-Mediated Regulation of Sodium Currents in Adult Purkinje Neurons Disrupts Firing and Impairs Motor Coordination and Balance.
Erratum issuedOpen access · goldAbstract read
In one paragraph
Article in Cell reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 27 papers.
0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed
1.6field-weighted citation impact, top 20% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
27 citing papers in PubMed, 48 citations in OpenAlex.
- Cerebellar microRNA-206 tunes Purkinje neuron firing dynamics to control sensorimotor gating.bioRxiv : the preprint server for biology · 2026Article
- In Vivo Expression of an SCA27A-LinkedThe Journal of neuroscience : the official journal of the Society for Neuroscience · 2026Article
- Epigenetic Control of an Auxiliary Subunit of Voltage-Gated Sodium Channels Regulates the Strength of Drug-Cue Associations and Relapse-Like Cocaine Seeking.Biological psychiatry · 2025Article
- A spatial single-cell atlas of the claustro-insular region uncovers key regulators of neuronal identity and excitability.Nature communications · 2025Article
- Loss of intracellular FGF14 (iFGF14) increases excitability of mature hippocampal pyramidal neurons.The Journal of general physiology · 2025Article
- Tsc1 deletion in Purkinje neurons disrupts the axon initial segment, impairing excitability and cerebellar function.Neurobiology of disease · 2025Article
- Article
- A Reinterpretation of the Relationship between Persistent and Resurgent Sodium Currents.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- A Reinterpretation of the Relationship Between Persistent and Resurgent Sodium Currents.bioRxiv : the preprint server for biology · 2024Article
- Phenotypical, genotypical and pathological characterization of the moonwalker mouse, a model of ataxia.Neurobiology of disease · 2024Article
- AAV-Mediated CAG-Targeting Selectively Reduces Polyglutamine-Expanded Protein and Attenuates Disease Phenotypes in a Spinocerebellar Ataxia Mouse Model.International journal of molecular sciences · 2024Article
- Characterization of NaLife science alliance · 2024Article
- Article
- Dynamic alteration of intrinsic properties of the cerebellar Purkinje cell during the motor memory consolidation.Molecular brain · 2023Article
- Transcriptional dynamics of murine motor neuron maturation in vivo and in vitro.Nature communications · 2022Article
- Article
- The difficulty to model Huntington's disease in vitro using striatal medium spiny neurons differentiated from human induced pluripotent stem cells.Scientific reports · 2021Article
- A role of oligodendrocytes in information processing.Nature communications · 2020Article
- Effects of FGF14 and NaThe Journal of general physiology · 2019Article
- Deletion of Class II ADP-Ribosylation Factors in Mice Causes Tremor by the Nav1.6 Loss in Cerebellar Purkinje Cell Axon Initial Segments.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2019Article
Corrections and comments
- Erratum issued
Authors and funding
7 authors at 1 institution in 1 country.
Joseph L RansdellDepartments of Developmental Biology and Internal Medicine , Washington University School of Medicine, St. Louis, MO 63110, USA.
Edward DranoffDepartments of Developmental Biology and Internal Medicine , Washington University School of Medicine, St. Louis, MO 63110, USA.
Brandon LauDepartments of Developmental Biology and Internal Medicine , Washington University School of Medicine, St. Louis, MO 63110, USA.
Wan-Lin LoDepartment of Pathology and Immunology , Washington University School of Medicine, St. Louis, MO 63110, USA.
David L DonermeyerDepartment of Pathology and Immunology , Washington University School of Medicine, St. Louis, MO 63110, USA.
Paul M AllenDepartment of Pathology and Immunology , Washington University School of Medicine, St. Louis, MO 63110, USA.
Jeanne M NerbonneDepartments of Developmental Biology and Internal Medicine , Washington University School of Medicine, St. Louis, MO 63110, USA. Electronic address: jnerbonne@wustl.edu.
Washington University in St. Louis · US
Funding
Washington University Center for Translational NeuroscienceP30NS057105 · NINDS · WASHINGTON UNIVERSITY · PI HOLTZMAN, DAVID M. · 2006 to 2011
$8.7MRECOGNITION AND SIGNALING IN POSITIVE SELECTION OF CD4+ T CELLSR01AI024157 · NIAID · WASHINGTON UNIVERSITY · PI ALLEN, PAUL M · 1987 to 2016
$2.5MFGF14 IN THE REGULATION OF PURKINJE NEURON EXCITABILITY AND SCA27R01NS065761 · NINDS · WASHINGTON UNIVERSITY · PI NERBONNE, JEANNE M., ORNITZ, DAVID M · 2009 to 2013
$1.9MiFGF14 Regulation of Cerebellar Neuron ExcitabilityF32NS090765 · NINDS · WASHINGTON UNIVERSITY · PI RANSDELL, JOSEPH L. · 2014 to 2017
$167kNIAID NIH HHS R01 AI024157NINDS NIH HHS F32 NS090765NINDS NIH HHS P30 NS057105NINDS NIH HHS R01 NS065761
Abstract
The resurgent component of voltage-gated Na
Indexed as
Ion Channel GatingAction PotentialsAgingAnimalsAnimals, NewbornCell DifferentiationCell SeparationFemaleGene DeletionGene Knockdown TechniquesGene TargetingMaleMice, Inbred C57BLMotor ActivityNeuronsPatch-Clamp TechniquesScn4b protein, mouseSodiumVoltage-Gated Sodium Channel beta-4 Subunitcerebellumdynamic clampresurgent sodium currentScn4b(−/−)Scn4b-targeted shRNA
Identifiers
What OpenQuestion holds
Textmetadata
LicenceTDM
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.