Evidence map›Paper›PMID 28423185›Full record

ArticleJournal of neurochemistry2017

Functional identification of activity-regulated, high-affinity glutamine transport in hippocampal neurons inhibited by riluzole.

Jeffrey D Erickson

Abstract read
In one paragraph

Article in Journal of neurochemistry, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
1.2field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 24 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Article
  6. Neurotransmitters in Prevention and Treatment of Alzheimer's Disease.International journal of molecular sciences · 2023
    Review
  7. CaCurrent research in physiology · 2023
    Article
  8. Targeting NMDA Receptor Complex in Management of Epilepsy.Pharmaceuticals (Basel, Switzerland) · 2022
    Review
  9. Article
  10. Glutamine Uptake via SNAT6 and Caveolin Regulates Glutamine-Glutamate Cycle.International journal of molecular sciences · 2021
    Article
  11. D-Serine Signaling and NMDAR-Mediated Synaptic Plasticity Are Regulated by System A-Type of Glutamine/D-Serine Dual Transporters.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2020
    Article
  12. Review
  13. Review
  14. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author at 1 institution in 1 country.

Jeffrey D EricksonNeuroscience Center of Excellence, School of Medicine, Lousiania State University Health New Orleans, New Orleans, Louisiana, USA.ORCID 0000-0003-4598-9898
Louisiana State University Health Sciences Center New Orleans · US

Funding

VGLUT2 Transmission in Prefrontal Cortex and Working MemoryR21MH101612 · NIMH · LSU HEALTH SCIENCES CENTER · PI ERICKSON, JEFFREY D · 2014 to 2015
$401k
NIMH NIH HHS R21 MH101612
6 · The paper itself

Abstract

Glutamine (Gln) is considered the preferred precursor for the neurotransmitter pool of glutamate (Glu), the major excitatory transmitter in the mammalian CNS. Here, an activity-regulated, high-affinity Gln transport system is described in developing and mature neuron-enriched hippocampal cultures that is potently inhibited by riluzole (IC

Indexed as

Amino Acid Transport System X-AGAnimalsAstrocytesbeta-AlanineCalciumCalcium Channel BlockersExcitatory Amino Acid AntagonistsFemaleGlutamineHippocampusNeuronsNeuroprotective AgentsPotassiumPregnancyRatsRats, Sprague-Dawley2,2-dimethyl-beta-alanineAmino Acid Transport System X-AGbeta-AlanineCalciumCalcium Channel BlockersExcitatory Amino Acid AntagonistsGlutamineNeuroprotective AgentsPotassiumRiluzoleactivity-dependent regulationexcitotoxicityglutamate/glutamine cycleneuronal glutamine transporterneuroprotectionneurotransmitter cycling

Identifiers

PMID28423185
PMCPMC5594568
OpenAlexW2606157808

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.