ArticlePloS one2017
Comparison of T2*-weighted and QSM contrasts in Parkinson's disease to visualize the STN with MRI.
Article in PloS one, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 2 of them syntheses that pooled it.
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Who cites it
29 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Quantitative Susceptibility Mapping and Resting State Network Analyses in Parkinsonian Phenotypes-A Systematic Review of the Literature.Frontiers in neural circuits · 2019Pooled it
- Present and Future of Ultra-High Field MRI in Neurodegenerative Disorders.Current neurology and neuroscience reports · 2018Pooled it
- Increased iron deposition in nucleus accumbens associated with disease progression and chronicity in migraine.BMC medicine · 2023Trial
- Reducing Variability in Deep Gray Matter QSM Using Differential ROI Referencing: A Phantom and In Vivo Evaluation.NMR in biomedicine · 2026Article
- A deep brain stimulation-conditioned RF coil for 3T MRI.Magnetic resonance in medicine · 2025Article
- Spherical echo-planar time-resolved imaging (sEPTI) for rapid 3D quantitativeMagnetic resonance in medicine · 2025Article
- Quantitative MRI at 7-Tesla reveals novel frontocortical myeloarchitecture anomalies in major depressive disorder.Translational psychiatry · 2024Article
- Computational Neurosurgery in Deep Brain Stimulation.Advances in experimental medicine and biology · 2024Review
- A Retrospective Comparison of Multiple Approaches to Anatomically Informed Contact Selection in Subthalamic Deep Brain Stimulation for Parkinson's Disease.Journal of Parkinson's disease · 2024Article
- Brainstem anatomy with 7-T MRI: in vivo assessment and ex vivo comparison.European radiology experimental · 2023Article
- Ultra-high-field 7T MRI in Parkinson's disease: ready for clinical use?-a narrative review.Quantitative imaging in medicine and surgery · 2023Review
- Direct localization and delineation of human pedunculopontine nucleus based on a self-supervised magnetic resonance image super-resolution method.Human brain mapping · 2023Article
- Brain pathological changes during neurodegenerative diseases and their identification methods: How does QSM perform in detecting this process?Insights into imaging · 2022Review
- Manual delineation approaches for direct imaging of the subcortex.Brain structure & function · 2022Article
- An Updated Overview of the Magnetic Resonance Imaging of Brain Iron in Movement Disorders.Behavioural neurology · 2022Review
- Safety and image quality at 7T MRI for deep brain stimulation systems: Ex vivo study with lead-only and full-systems.PloS one · 2021Article
- Article
- Methodological Considerations for Neuroimaging in Deep Brain Stimulation of the Subthalamic Nucleus in Parkinson's Disease Patients.Journal of clinical medicine · 2020Article
- The TRACK-PD study: protocol of a longitudinal ultra-high field imaging study in Parkinson's disease.BMC neurology · 2020Article
- 3 versus 7 Tesla magnetic resonance imaging for parcellations of subcortical brain structures in clinical settings.PloS one · 2020Article
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Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The subthalamic nucleus (STN) plays a crucial role in the surgical treatment of Parkinson's disease (PD). Studies investigating optimal protocols for STN visualization using state of the art magnetic resonance imaging (MRI) techniques have shown that susceptibility weighted images, which display the magnetic susceptibility distribution, yield better results than T1-weighted, T2-weighted, and T2*-weighted contrasts. However, these findings are based on young healthy individuals, and require validation in elderly individuals and persons suffering from PD. Using 7T MRI, the present study set out to investigate which MRI contrasts yielded the best results for STN visualization in 12 PD patients and age-matched healthy controls (HC). We found that STNs were more difficult to delineate in PD as reflected by a lower inter-rater agreement when compared to HCs. No STN size differences were observed between the groups. Analyses of quantitative susceptibility mapping (QSM) images showed a higher inter-rater agreement reflected by increased Dice-coefficients. The location of the center of mass of the STN was not affected by contrast. Overall, contrast-to-noise ratios (CNR) were higher in QSM than in T2*-weighted images. This can at least partially, explain the higher inter-rater agreement in QSM. The current results indicate that the calculation of QSM contrasts contributes to an improved visualization of the entire STN. We conclude that QSM contrast is the preferred choice for the visualization of the STN in persons with PD as well as in aging HC.
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