ArticlePloS one2017
Inbreeding and selection shape genomic diversity in captive populations: Implications for the conservation of endangered species.
Article in PloS one, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed.
- A Beginner's How-To Guide to Urban Population Genetics and Genomics.Ecology and evolution · 2026Review
- Article
- Persistent Genomic Erosion in Whooping Cranes Despite Demographic Recovery.Molecular ecology · 2025Article
- Evaluating Kinship Estimation Methods for Reduced-Representation SNP Data in Non-model Species.Molecular ecology resources · 2025Article
- A universally applicable definition for domestication.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Exploring the Genetic Diversity of the Jewel BeetlesInsects · 2025Article
- Digital Image Processing to Detect Adaptive Evolution.Molecular biology and evolution · 2024Article
- Translating genomic advances into biodiversity conservation.Nature reviews. Genetics · 2024Review
- Epigenetic changes to gene pathways linked to male fertility in ex situ black-footed ferrets.Evolutionary applications · 2024Article
- The Weight of Genetic Drift: A Pedigree-Based Evaluation of the Breton Horse Population in Brazil.Veterinary medicine international · 2024Article
- Exploiting genomic synteny in Felidae: cross-species genome alignments and SNV discovery can aid conservation management.BMC genomics · 2021Article
- Cranial morphology of captive mammals: a meta-analysis.Frontiers in zoology · 2021Article
- Article
- Captive-reared migratory monarch butterflies show natural orientation when released in the wild.Conservation physiology · 2021Article
- Chromosomal-level genome assembly of the scimitar-horned oryx: Insights into diversity and demography of a species extinct in the wild.Molecular ecology resources · 2020Article
- Review
- Article
- Genetic Effects on Dispersion in Urinary Albumin and Creatinine in Three House Mouse (G3 (Bethesda, Md.) · 2019Article
- Next-generation metrics for monitoring genetic erosion within populations of conservation concern.Evolutionary applications · 2018Review
- Article
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Authors and funding
5 authors.
Funding
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Abstract
Captive breeding programs are often initiated to prevent species extinction until reintroduction into the wild can occur. However, the evolution of captive populations via inbreeding, drift, and selection can impair fitness, compromising reintroduction programs. To better understand the evolutionary response of species bred in captivity, we used nearly 5500 single nucleotide polymorphisms (SNPs) in populations of white-footed mice (Peromyscus leucopus) to measure the impact of breeding regimes on genomic diversity. We bred mice in captivity for 20 generations using two replicates of three protocols: random mating (RAN), selection for docile behaviors (DOC), and minimizing mean kinship (MK). The MK protocol most effectively retained genomic diversity and reduced the effects of selection. Additionally, genomic diversity was significantly related to fitness, as assessed with pedigrees and SNPs supported with genomic sequence data. Because captive-born individuals are often less fit in wild settings compared to wild-born individuals, captive-estimated fitness correlations likely underestimate the effects in wild populations. Therefore, minimizing inbreeding and selection in captive populations is critical to increasing the probability of releasing fit individuals into the wild.
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