SynthesisPloS one2017
The impact of atosiban on pregnancy outcomes in women undergoing in vitro fertilization-embryo transfer: A meta-analysis.
Synthesis in PloS one, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 4 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
15 citing papers in PubMed, 4 syntheses or guidelines pooled it, 38 citations in OpenAlex.
- Treatment Effects in Randomized and Nonrandomized Studies of Pharmacological Interventions: A Meta-Analysis.JAMA network open · 2024Pooled it
- Efficacy of atosiban for repeated embryo implantation failure: A systematic review and meta-analysis.Frontiers in endocrinology · 2023Pooled it
- Oxytocin antagonists for assisted reproduction.The Cochrane database of systematic reviews · 2021Pooled it
- Efficacy of therapies and interventions for repeated embryo implantation failure: a systematic review and meta-analysis.Scientific reports · 2021Pooled it
- A randomized double blind comparison of atosiban in patients with recurrent implantation failure undergoing IVF treatment.Reproductive biology and endocrinology : RB&E · 2022Trial
- Abnormal endometrial peristalsis in frozen-thawed embryo transfer: risk factors and improvement of Atosiban treatment.Reproduction & fertility · 2025Article
- The effect of atosiban on pregnancy outcomes in different FET cycles: a single-center matched retrospective cohort study.Frontiers in endocrinology · 2025Article
- Effects of atosiban on clinical outcome in frozen-thawed embryo transfer: a propensity score matching study.Archives of gynecology and obstetrics · 2024Article
- Article
- Efficacy of atosiban for repeated implantation failure in frozen embryo transfer cycles.Scientific reports · 2023Article
- Article
- Efficacy of atosiban combined with ritodrine in the treatment of threatened preterm labor and related risk factors of different pregnancy outcomes.American journal of translational research · 2022Article
- Comparison of frozen-thawed embryo transfer protocols in patients with previous cycle cancellation due to uterine peristalsis: a pilot studyTurkish journal of medical sciences · 2021Article
- Approaches to Improve Endometrial Receptivity in Case of Repeated Implantation Failures.Frontiers in cell and developmental biology · 2021Review
- Utilizing Artificial Intelligence in Cine Magnetic Resonance Imaging Analysis: A Promising Approach for Assessment of Uterine Factors and Prediction of Pregnancy Outcomes in Patients With Recurrent Implantation Failure.Reproductive medicine and biologyArticle
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAtosiban is administered to women undergoing in vitro fertilization-embryo transfer (IVF-ET) to improve pregnancy outcomes. However, the results of this treatment were controversial. We conducted this meta-analysis to investigate whether atosiban improves pregnancy outcomes in the women undergoing in vitro fertilization (IVF).
methodsDatabases of PubMed, EMBASE, Web of Science, China BioMedicine, and Google Scholar were systematically searched. Meta-analyses were performed to investigate whether atosiban improves pregnancy outcomes in the women undergoing IVF.
resultsOur results showed that atosiban was associated with higher implantation (OR = 1.63, 95% CI: 1.17-2.27; P = 0.004) and clinical pregnancy (OR = 1.84, 95% CI: 1.31-2.57; P < 0.001) rates. However, atosiban showed no significant association with the miscarriage, live birth, multiple pregnancy or ectopic pregnancy rates. When a further subgroup analysis was performed in the women undergoing repeated implantation failure (RIF), implantation (OR = 1.93, 95% CI: 1.45-2.57; P < 0.001), clinical pregnancy (OR = 2.48, 95% CI: 1.70-3.64; P <0.001) and the live birth (OR = 2.89, 95% CI: 1.78-4.67; P < 0.001) rates were significantly higher in the case group. Nevertheless, no significant difference was detected in the miscarriage and multiple pregnancy rates between the case and control groups.
conclusionAtosiban may be more appropriate for women undergoing RIF and play only a limited role in improving pregnancy outcomes in the general population of women undergoing IVF. These conclusions should be verified in large and well-designed studies.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.