ArticlePloS one2017
Challenges in enumeration of CTCs in breast cancer using techniques independent of cytokeratin expression.
Article in PloS one, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
11 citing papers in PubMed, 17 citations in OpenAlex.
- Circulating tumor cells: Blood-based detection, molecular biology, and clinical applications.Cancer cell · 2025Review
- SERS biosensors for liquid biopsy towards cancer diagnosis by detection of various circulating biomarkers: current progress and perspectives.Nano convergence · 2024Review
- Clinical impact of high-quality testing for peritoneal lavage cytology in pancreatic cancer.Scientific reports · 2024Article
- Breast cancer circulating tumor cells with mesenchymal features-an unreachable target?Cellular and molecular life sciences : CMLS · 2022Review
- Article
- Article
- Clinical value and feasibility of ISET in detecting circulating tumor cells in early breast cancer.Translational cancer research · 2020Article
- Review
- CTC phenotyping for a preoperative assessment of tumor metastasis and overall survival of pancreatic ductal adenocarcinoma patients.EBioMedicine · 2019Article
- Liquid Biopsies in Lung Cancer: Four Emerging Technologies and Potential Clinical Applications.Cancers · 2019Article
- An update of circulating rare cell types in healthy adult peripheral blood: findings of immature erythroid precursors.Annals of translational medicine · 2018Article
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 2 countries.
Funding
Abstract
introductionGiven the current postulated plasticity between epithelial and mesenchymal states of migratory cancer cells the detection of non-epithelial CTCs is an important scientific and clinical goal.
methodsWe used the filtration-based ISET technology to enrich circulating tumour cells (CTCs) in early breast cancer blood samples and identify them using a morphology-based immunocytochemistry (ICC) approach.
resultsWe found greater numbers of putative CTCs by this approach than by the cytokeratin-based CellSearch technology, but a high number of CTC false positives were identified in healthy volunteer samples which were not reduced in successive blood draws. Preliminary work using an oestrogen receptor (ER)-based multiplex ICC method in metastatic breast cancer ISET samples indicated a low number of ER+ CTCs even at this advanced stage.
conclusionsThis work highlights the challenges in enumerating CTCs without conventional epithelial markers.
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Registered trials
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