ArticlePLoS neglected tropical diseases2017
The gut microbiota as a modulator of innate immunity during melioidosis.
Article in PLoS neglected tropical diseases, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
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Who cites it
35 citing papers in PubMed, 52 citations in OpenAlex.
- Gut microbiota-driven IL-17A production by hepatic γδ T cells enhances neutrophil defense against systemicVirulence · 2026Article
- The Role of the Respiratory Microbiome in Pneumonia.Clinics in chest medicine · 2026Review
- Prospective association between the gut microbiota and incident pneumonia: a cohort study of 6419 individuals.Respiratory research · 2025Article
- Article
- Altered gut microbiota and metabolite profiles in community-acquired pneumonia: a metagenomic and metabolomic study.Microbiology spectrum · 2025Article
- Fluoroquinolones directly drive mitochondrial hyperpolarization and modulate iNOS expression in monocyte-derived macrophage populations.Discovery immunology · 2025Article
- Gut dysbiosis was inevitable, but tolerance was not: temporal responses of the murine microbiota that maintain its capacity for butyrate production correlate with sustained antinociception to chronic morphine.bioRxiv : the preprint server for biology · 2024Article
- Gut Microbiome in Human Melioidosis: Composition and Resistome Dynamics from Diagnosis to Discovery.Open forum infectious diseases · 2024Article
- Neutralizing gut-derived lipopolysaccharide as a novel therapeutic strategy for severe leptospirosis.eLife · 2024Article
- Exploring the complex interplay: gut microbiome, stress, and leptospirosis.Frontiers in microbiology · 2024Review
- Alveolar macrophage modulation via the gut-lung axis in lung diseases.Frontiers in immunology · 2023Review
- Rectal microbiota are coupled with altered cytokine production capacity following community-acquired pneumonia hospitalization.iScience · 2022Article
- Microbiome-Independent Effects of Antibiotics in a Murine Model of Nosocomial Infections.mBio · 2022Article
- Long-distance relationships - regulation of systemic host defense against infections by the gut microbiota.Mucosal immunology · 2022Review
- Plant Polysaccharides Modulate Immune Function via the Gut Microbiome and May Have Potential in COVID-19 Therapy.Molecules (Basel, Switzerland) · 2022Review
- Gut microbiota involved in leptospiral infections.The ISME journal · 2022Article
- Chronic Critical Illness: Current Aspects of the Problem (Review).Sovremennye tekhnologii v meditsine · 2022Review
- Rectal bacteriome and virome signatures and clinical outcomes in community-acquired pneumonia: An exploratory study.EClinicalMedicine · 2021Article
- Pulmonary and intestinal microbiota dynamics during Gram-negative pneumonia-derived sepsis.Intensive care medicine experimental · 2021Article
- Gut Microbiota Contributes to Host Defense AgainstJournal of inflammation research · 2021Article
Corrections and comments
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Authors and funding
11 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundMelioidosis, caused by the Gram-negative bacterium Burkholderia pseudomallei, is an emerging cause of pneumonia-derived sepsis in the tropics. The gut microbiota supports local mucosal immunity and is increasingly recognized as a protective mediator in host defenses against systemic infection. Here, we aimed to characterize the composition and function of the intestinal microbiota during experimental melioidosis. METHODOLOGY/PRINCIPAL
findingsC57BL/6 mice were infected intranasally with B. pseudomallei and sacrificed at different time points to assess bacterial loads and inflammation. In selected experiments, the gut microbiota was disrupted with broad-spectrum antibiotics prior to inoculation. Fecal bacterial composition was analyzed by means of IS-pro, a 16S-23S interspacer region-based profiling method. A marked shift in fecal bacterial composition was seen in all mice during systemic B. pseudomallei infection with a strong increase in Proteobacteria and decrease in Actinobacteria, with an increase in bacterial diversity. We found enhanced early dissemination of B. pseudomallei and systemic inflammation during experimental melioidosis in microbiota-disrupted mice compared with controls. Whole-genome transcriptional profiling of the lung identified several genes that were differentially expressed between mice with a normal or disrupted intestinal microbiota. Genes involved in acute phase signaling, including macrophage-related signaling pathways were significantly elevated in microbiota disrupted mice. Compared with controls, alveolar macrophages derived from antibiotic pretreated mice showed a diminished capacity to phagocytose B. pseudomallei. This might in part explain the observed protective effect of the gut microbiota in the host defense against pneumonia-derived melioidosis. CONCLUSIONS/SIGNIFICANCE: Taken together, these data identify the gut microbiota as a potential modulator of innate immunity during B. pseudomallei infection.
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