ArticlePediatric research2017
Pediatric Cushing disease: disparities in disease severity and outcomes in the Hispanic and African-American populations.
Article in Pediatric research, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 2 of them syntheses that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
15 citing papers in PubMed, 2 syntheses or guidelines pooled it, 30 citations in OpenAlex.
- Impact of social factors on outcomes following pediatric neuro-oncology surgery in the United States: a systematic review and meta-analysis.Neurosurgical review · 2025Pooled it
- Racial and ethnic disparities among children with primary central nervous system tumors in the US.Journal of neuro-oncology · 2021Pooled it
- Biases of large language models in diagnosing Cushing's syndrome.World journal of methodology · 2026Review
- Article
- Cushing disease in pediatrics: an update.Annals of pediatric endocrinology & metabolism · 2023Article
- Neurosurgical aspects and clinical outcomes on the treatment of Cushing disease in pediatric patients: Case series and literature review.Surgical neurology international · 2023Article
- Machine intelligence in non-invasive endocrine cancer diagnostics.Nature reviews. Endocrinology · 2022Review
- Racial Disparities in Acromegaly and Cushing's Disease: A Referral Center Study in 241 Patients.Journal of the Endocrine Society · 2022Article
- Paediatric Cushing's disease: Epidemiology, pathogenesis, clinical management and outcome.Reviews in endocrine & metabolic disorders · 2021Review
- Lipoprotein particles in patients with pediatric Cushing disease and possible cardiovascular risks.Pediatric research · 2019Article
- Large Genomic Aberrations in Corticotropinomas Are Associated With Greater Aggressiveness.The Journal of clinical endocrinology and metabolism · 2019Article
- Aortic pulse wave velocity in children with Cushing syndrome: A window into a marker of early cardiovascular disease.Endocrinology, diabetes & metabolism · 2019Article
- Cushing's Syndrome in Pediatrics: An Update.Endocrinology and metabolism clinics of North America · 2018Review
- Neonatal Cushing Syndrome: A Rare but Potentially Devastating Disease.Clinics in perinatology · 2018Review
- Policy solutions to recruiting and retaining minority children in research.Pediatric research · 2017Article
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Authors and funding
11 authors at 5 institutions in 1 country.
Funding
Abstract
BackgroundLittle is known about the contribution of racial and socioeconomic disparities to severity and outcomes in children with Cushing disease (CD).MethodsA total of 129 children with CD, 45 Hispanic/Latino or African-American (HI/AA) and 84 non-Hispanic White (non-HW), were included in this study. A 10-point index for rating severity (CD severity) incorporated the degree of hypercortisolemia, glucose tolerance, hypertension, anthropomorphic measurements, disease duration, and tumor characteristics. Race, ethnicity, age, gender, local obesity prevalence, estimated median income, and access to care were assessed in regression analyses of CD severity.ResultsThe mean CD severity in the HI/AA group was worse than that in the non-HW group (4.9±2.0 vs. 4.1±1.9, P=0.023); driving factors included higher cortisol levels and larger tumor size. Multiple regression models confirmed that race (P=0.027) and older age (P=0.014) were the most important predictors of worse CD severity. When followed up a median of 2.3 years after surgery, the relative risk for persistent CD combined with recurrence was 2.8 times higher in the HI/AA group compared with that in the non-HW group (95% confidence interval: 1.2-6.5).ConclusionOur data show that the driving forces for the discrepancy in severity of CD are older age and race/ethnicity. Importantly, the risk for persistent and recurrent CD was higher in minority children.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.