SynthesisMedicine2017
Association between diabetes mellitus and subsequent ovarian cancer in women: A systematic review and meta-analysis of cohort studies.
Synthesis in Medicine, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 4 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
12 citing papers in PubMed, 4 syntheses or guidelines pooled it, 21 citations in OpenAlex.
- Physical activity, sedentary behavior and ovarian cancer risk in Asian populations: a scoping review and meta-analysis.BMC cancer · 2026Pooled it
- Diabetes and anti-diabetic interventions and the risk of gynaecological and obstetric morbidity: an umbrella review of the literature.BMC medicine · 2023Pooled it
- Type 2 Diabetes and Cancer: An Umbrella Review of Observational and Mendelian Randomization Studies.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2021Pooled it
- Diabetes mellitus and the risk of ovarian cancer: a systematic review and meta-analysis of cohort and case-control studies.BMJ open · 2020Pooled it
- Diabetes mellitus and the risk of ovarian cancer: an updated systematic review and meta-analysis of cohort and case-control studies.Diabetology & metabolic syndrome · 2025Review
- The protective effect of sodium-glucose cotransporter 2 inhibitors and the incidence of ovarian cancer: a nationwide cohort preliminary study.Archives of medical science : AMS · 2025Article
- Adherence to diabetes risk reduction diet and the risk of head and neck cancer: a prospective study of 101,755 American adults.Frontiers in nutrition · 2023Article
- Prospective associations of hemoglobin ACancer research communications · 2022Article
- Insulin Resistance and Cancer: In Search for a Causal Link.International journal of molecular sciences · 2021Review
- Clinical Implication of Metformin in Relation to Diabetes Mellitus and Ovarian Cancer.Biomedicines · 2021Review
- Diabetes and cancer: Epidemiological and biological links.World journal of diabetes · 2020Review
- Diabetes and cancer: A comprehensive review.Journal of research in medical sciences : the official journal of Isfahan University of Medical Sciences · 2019Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Epidemiologic studies have suggested that diabetes mellitus (DM) might be associated with risk of ovarian cancer; however, the results have been inconsistent. The aim of this study was to determine the relationship between DM and the incidence of ovarian cancer on the basis of cohort studies.Relevant studies from PubMed, Embase, and the Cochrane Library until September 2016 were collected. The summary risk ratio (RR) was used as the effect measure in a random effects model. Sensitivity analysis, subgroup analysis, and calculation of publication bias were conducted.Thirteen articles including 14 cohorts comprising a total of 3708, 313 women and reporting 5534 cases of ovarian cancer were included. The summary RR suggested that patients with DM had a higher risk of ovarian cancer than patients without DM (RR: 1.19; 95% confidence interval: 1.06-1.34; P = .004), and no evidence of publication bias was found. The subgroup analysis indicated a higher incidence of ovarian cancer in patients with DM in studies published after 2010, studies not conducted in Europe or the United States, studies that did not adjust for body mass index or smoking status, and studies with lower Newcastle-Ottawa Scale scores.The present findings indicated that DM is a risk factor for ovarian cancer, and future large-scale epidemiologic studies should be performed to evaluate this relation in specific populations.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.