Evidence map›Paper›PMID 28422567›Full record

ArticleHuman vaccines & immunotherapeutics2017

Evaluation of serotypes 5 and 8 capsular polysaccharides in protection against Staphylococcus aureus in murine models of infection.

Brian L Cheng, Travis B Nielsen, Paul Pantapalangkoor, Fan Zhao, Jean C Lee, Christopher P Montgomery, Brian Luna, Brad Spellberg, Robert S Daum

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Human vaccines & immunotherapeutics, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
0.8field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 16 citations in OpenAlex.

  1. Trial
  2. Overcoming Immune Evasion inACS infectious diseases · 2025
    Review
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  5. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Brian L Chenga Department of Microbiology , University of Chicago , Chicago , IL , USA.
Travis B Nielsenb Departments of Medicine and Molecular Microbiology and Immunology , Keck School of Medicine, University of Southern California , Los Angeles , CA , USA.
Paul Pantapalangkoorb Departments of Medicine and Molecular Microbiology and Immunology , Keck School of Medicine, University of Southern California , Los Angeles , CA , USA.
Fan Zhaoc Department of Pediatrics , University of Chicago , Chicago , IL , USA.
Jean C Leed Division of Infectious Diseases, Department of Medicine , Brigham and Women's Hospital and Harvard Medical School , Boston , MA , USA.
Christopher P Montgomeryc Department of Pediatrics , University of Chicago , Chicago , IL , USA.
Brian Lunab Departments of Medicine and Molecular Microbiology and Immunology , Keck School of Medicine, University of Southern California , Los Angeles , CA , USA.
Brad Spellbergb Departments of Medicine and Molecular Microbiology and Immunology , Keck School of Medicine, University of Southern California , Los Angeles , CA , USA.
Robert S Daumc Department of Pediatrics , University of Chicago , Chicago , IL , USA.
University of Chicago · USUniversity of Southern California · USHarvard University · US

Funding

A New Approach to Staphylococcus aureus Vaccine Development - Resubmission 01R01AI103342 · NIAID · UNIVERSITY OF MARYLAND BALTIMORE · PI DAUM, ROBERT S., LEE, JEAN CLAIRE · 2013 to 2016
$2.1M
NIAID NIH HHS R01 AI103342
6 · The paper itself

Abstract

Staphylococcus aureus is the leading cause of nosocomial and community-acquired infections, including soft tissue and skin infections and bacteremia. However, efforts to develop an effective vaccine against S. aureus infections have not been successful. We evaluated serotypes 5 and 8 capsule polysaccharides (CP) CRM

Indexed as

SerogroupAdjuvants, ImmunologicAnimalsAntibodies, BacterialBacteremiaBacterial LoadBacterial ProteinsDisease Models, AnimalFemaleHumansMice, Inbred BALB CPolysaccharides, BacterialStaphylococcal InfectionsStaphylococcal Skin InfectionsStaphylococcal VaccinesStaphylococcus aureusAdjuvants, ImmunologicAntibodies, BacterialBacterial ProteinsCRM197 (non-toxic variant of diphtheria toxin)Polysaccharides, BacterialStaphylococcal VaccinesVaccines, ConjugateCapsular polysaccharidesStaphylococcus aureusvaccine

Identifiers

PMID28422567
PMCPMC5512765
OpenAlexW2607013546

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.