Evidence map›Paper›PMID 28422190›Full record

ArticleScientific reports2017

Current carried by the Slc26 family member prestin does not flow through the transporter pathway.

Jun-Ping Bai, Iman Moeini-Naghani, Sheng Zhong, Fang-Yong Li, Shumin Bian, Fred J Sigworth, Joseph Santos-Sacchi, Dhasakumar Navaratnam

Open access · goldAbstract read
In one paragraph

Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
0.9field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 18 citations in OpenAlex.

  1. Article
  2. Synthesis of Novel Anion Recognition Molecules as Quinazoline Precursors.International journal of molecular sciences · 2025
    Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Outer Hair Cells and Electromotility.Cold Spring Harbor perspectives in medicine · 2019
    Review
  10. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Jun-Ping BaiDept. of Neurology, Yale School of Medicine, 333 Cedar Street, New Haven, CT, 06510 USA.
Iman Moeini-NaghaniDept. of Neurology, Yale School of Medicine, 333 Cedar Street, New Haven, CT, 06510 USA.
Sheng ZhongDept. of Surgery, Yale School of Medicine, 333 Cedar Street, New Haven, CT, 06510 USA.
Fang-Yong LiYale Center for Analytical Sciences, Yale School of Public Health, 300 George St., Ste Suite 555, New Haven, CT 06511, USA.
Shumin BianDept. of Neurology, Yale School of Medicine, 333 Cedar Street, New Haven, CT, 06510 USA.
Fred J SigworthDept. of Cellular and Molecular Physiology, Yale School of Medicine, 333 Cedar Street, New Haven, CT, 06510, USA.
Joseph Santos-SacchiDept. of Surgery, Yale School of Medicine, 333 Cedar Street, New Haven, CT, 06510 USA.
Dhasakumar NavaratnamDept. of Neurology, Yale School of Medicine, 333 Cedar Street, New Haven, CT, 06510 USA.
Yale University · USYale New Haven Health System · US

Funding

Yale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9M
FLUCTUATIONS IN IONIC CURRENT THROUGH MEMBRANE CHANNELSR01NS021501 · NINDS · YALE UNIVERSITY · PI SIGWORTH, FREDERICK J · 1985 to 2024
$10.9M
Structural correlates of prestin activity.R01DC008130 · NIDCD · YALE UNIVERSITY · PI NAVARATNAM, DHASAKUMAR S, SANTOS-SACCHI, JOSEPH R · 2007 to 2021
$6.1M
NCATS NIH HHS UL1 TR001863NIDCD NIH HHS R01 DC008130NINDS NIH HHS R01 NS021501
6 · The paper itself

Abstract

Prestin in the lateral membrane of outer hair cells, is responsible for electromotility (EM) and a corresponding nonlinear capacitance (NLC). Prestin's voltage sensitivity is influenced by intracellular chloride. A regulator of intracellular chloride is a stretch-sensitive, non-selective conductance within the lateral membrane, G

Indexed as

Sulfate TransportersAnimalsCHO CellsCricetulusHEK293 CellsHumansIon Channel GatingIon TransportMutationProtein Structure, SecondarySLC26A5 protein, humanSulfate Transporters

Identifiers

PMID28422190
PMCPMC5395958
OpenAlexW2606621483

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.