Evidence map›Paper›PMID 28422186›Full record

ArticleMucosal immunology2017

High-fat diet induces systemic B-cell repertoire changes associated with insulin resistance.

T D Pham, M H Y Chng, K M Roskin, K J L Jackson, K D Nguyen, J Glanville, J-Y Lee, E G Engleman, S D Boyd

Open access · bronzeAbstract read
PubMed Publisher
In one paragraph

Article in Mucosal immunology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
0.7field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 27 citations in OpenAlex.

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  12. B Lymphocytes and Adipose Tissue Inflammation.Arteriosclerosis, thrombosis, and vascular biology · 2020
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

T D PhamDepartment of Pathology, Stanford University, Stanford, California, USA.
M H Y ChngDepartment of Pathology, Stanford University, Stanford, California, USA.
K M RoskinDepartment of Pathology, Stanford University, Stanford, California, USA.
K J L JacksonDepartment of Pathology, Stanford University, Stanford, California, USA.
K D NguyenDepartment of Pathology, Stanford University, Stanford, California, USA.
J GlanvilleDepartment of Pathology, Stanford University, Stanford, California, USA.
J-Y LeeDepartment of Pathology, Stanford University, Stanford, California, USA.
E G EnglemanDepartment of Pathology, Stanford University, Stanford, California, USA.
S D BoydDepartment of Pathology, Stanford University, Stanford, California, USA.
Stanford University · USStanford Blood Center · US

Funding

Defining Adaptive Immune Mechanisms of Insulin ResistanceR01DK096038 · NIDDK · STANFORD UNIVERSITY · PI ENGLEMAN, EDGAR G. · 2012 to 2015
$1.5M
NIDDK NIH HHS R01 DK096038
6 · The paper itself

Abstract

The development of obesity-associated insulin resistance is associated with B-lymphocyte accumulation in visceral adipose tissue (VAT) and is prevented by B-cell ablation. To characterize potentially pathogenic B-cell repertoires in this disorder, we performed high-throughput immunoglobulin (Ig) sequencing from multiple tissues of mice fed high-fat diet (HFD) and regular diet (RD). HFD significantly changed the biochemical properties of Ig heavy-chain complementarity-determining region-3 (CDRH3) sequences, selecting for IgA antibodies with shorter and more hydrophobic CDRH3 in multiple tissues. A set of convergent antibodies of highly similar sequences found in the VAT of HFD mice but not RD mice showed significant somatic mutation, suggesting a response shared between mice to a common antigen or antigens. These findings indicate that a simple high-fat dietary intervention has a major impact on mouse B-cell repertoires, particularly in adipose tissues.

Indexed as

AnimalsB-LymphocytesCell MovementCells, CulturedComplementarity Determining RegionsDiet, High-FatHigh-Throughput Nucleotide SequencingImmunoglobulin AInflammationInsulin ResistanceIntra-Abdominal FatMaleMiceMice, Inbred C57BLObesityReceptors, Antigen, B-CellComplementarity Determining RegionsImmunoglobulin AReceptors, Antigen, B-Cell

Identifiers

PMID28422186
OpenAlexW2607019199

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.