ArticleScientific reports2017
Detection of a new pyrethroid resistance mutation (V410L) in the sodium channel of Aedes aegypti: a potential challenge for mosquito control.
Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 118 papers.
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Who cites it
118 citing papers in PubMed, 223 citations in OpenAlex.
- The entomological impact of passive metofluthrin emanators against indoor Aedes aegypti: A randomized field trial.PLoS neglected tropical diseases · 2021Trial
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- The Evolution of Knockdown Resistance: Genotypic and Phenotypic Insights IntoEvolutionary applications · 2026Article
- Developmental Consequences of Early-Life Exposure and Adulticidal Effects ofMolecules (Basel, Switzerland) · 2026Article
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- Pepper Constituents Enhance the Toxicity and Neurophysiological Effects of Natural Pyrethrins in Insects.Insects · 2026Article
- Discovery of two novel mutations, R52H and N868D, in the voltage-gated sodium channel of Aedes aegypti associated with pyrethroid resistance.PLoS neglected tropical diseases · 2026Article
- Furin as target for suppression of mosquito-borne viruses.Virology journal · 2026Article
- Rising of pyrethroid resistance mutations (kdr) in the dengue vectorFrontiers in public health · 2026Article
- The contribution of transposable element insertions to genetic diversity inbioRxiv : the preprint server for biology · 2025Article
- Molecular characterization of invasive Aedes albopictus (Diptera: Culicidae) populations in northwest Iran: Insights into origin, insecticide resistance, and Wolbachia infection.Parasites & vectors · 2025Article
- Pyrethroid resistance in Aedes aegypti: genetic mechanisms worldwide, and recommendations for effective vector control.Parasites & vectors · 2025Review
- First report of the pyrethroid-resistance-associated V1016I mutation in Aedes aegypti at the seaport of Cotonou, Benin, West Africa.Tropical medicine and health · 2025Article
- Global distribution and impact of knockdown resistance mutations in Aedes aegypti on pyrethroid resistance.Parasites & vectors · 2025Review
- Mechanisms and Genetic Drivers of Resistance of Insect Pests to Insecticides and Approaches to Its Control.Toxics · 2025Review
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- Association of knockdown resistance mutations with pyrethroid resistance in Aedes aegypti, a major arbovirus vector in Cameroon.Parasites & vectors · 2025Article
- Profiling insecticide resistance phenotypes and genotypes in Aedes aegypti populations across four regions in Puerto Rico.Scientific reports · 2025Article
58 more citing papers are in PubMed but not listed here.
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Authors and funding
8 authors at 2 institutions in 2 countries.
Funding
Abstract
The yellow fever mosquito, Aedes aegypti, particularly in Neotropical regions, is the principal vector of dengue, yellow fever, Zika and Chikungunya viruses. Pyrethroids remain one of the most used insecticides to control Aedes mosquitoes, despite the development of pyrethroid resistance in many mosquito populations worldwide. Here, we report a Brazilian strain of A. aegypti with high levels (approximately 100-60,000 fold) of resistance to both type I and type II pyrethroids. We detected two mutations (V410L and F1534C) in the sodium channel from this resistant strain. This study is the first report of the V410L mutation in mosquitoes. Alone or in combination with the F1534C mutation, the V410L mutation drastically reduced the sensitivity of mosquito sodium channels expressed in Xenopus oocytes to both type I and type II pyrethroids. The V410L mutation presents a serious challenge for the control of A. aegypti and will compromise the use of pyrethroids for the control of A. aegypti in Brazil; therefore, early monitoring of the frequency of the V410L mutation will be a key resistance management strategy to preserve the effectiveness of pyrethroid insecticides.
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