Trial reportScientific reports2017
Abnormal resting-state functional connectivity in the orbitofrontal cortex of heroin users and its relationship with anxiety: a pilot fNIRS study.
Trial report in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 34 citations in OpenAlex.
- Principles, Applications, and Future Evolution of Agricultural Nondestructive Testing Based on Microwaves.Sensors (Basel, Switzerland) · 2025Review
- Neurobiological Mechanisms of Action of Transcranial Direct Current Stimulation (tDCS) in the Treatment of Substance Use Disorders (SUDs)-A Review.Journal of clinical medicine · 2025Review
- Inter-brain synchrony between undergraduate students during a naturalistic online seminar predicted greater relational satisfaction and task performance.Frontiers in neuroscience · 2025Article
- Examination of reward processing dysfunctions in the left dorsal striatum and other brain regions among psychiatric inpatients with substance use.Drug and alcohol dependence · 2024Article
- Article
- Effect of Shift Work on Cognitive Function in Chinese Coal Mine Workers: A Resting-State fNIRS Study.International journal of environmental research and public health · 2022Article
- Is There a Difference in Brain Functional Connectivity between Chinese Coal Mine Workers Who Have Engaged in Unsafe Behavior and Those Who Have Not?International journal of environmental research and public health · 2022Article
- Abnormal resting-state functional connectome in methamphetamine-dependent patients and its application in machine-learning-based classification.Frontiers in neuroscience · 2022Article
- Recognition of Flexion and Extension Imagery Involving the Right and Left Arms Based on Deep Belief Network and Functional Near-Infrared Spectroscopy.Journal of healthcare engineering · 2021Article
- Spectral clustering-based resting-state network detection approach for functional near-infrared spectroscopy.Biomedical optics express · 2020Article
- Machine learning: assessing neurovascular signals in the prefrontal cortex with non-invasive bimodal electro-optical neuroimaging in opiate addiction.Scientific reports · 2019Article
- Functional near-infrared spectroscopy-informed neurofeedback: regional-specific modulation of lateral orbitofrontal activation and cognitive flexibility.Neurophotonics · 2019Article
- Article
- Forging Neuroimaging Targets for Recovery in Opioid Use Disorder.Frontiers in psychiatry · 2019Review
- Article
- Which is more costly in Chinese to English simultaneous interpreting, "pairing" or "transphrasing"? Evidence from an fNIRS neuroimaging study.Neurophotonics · 2018Article
- Emotion recognition and its relation to prefrontal function and network in heroin plus nicotine dependence: a pilot study.Neurophotonics · 2018Article
- Spontaneous activity in medial orbitofrontal cortex correlates with trait anxiety in healthy male adults.Journal of Zhejiang University. Science. BArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Drug addiction is widely linked to the orbitofrontal cortex (OFC), which is essential for regulating reward-related behaviors, emotional responses, and anxiety. Over the past two decades, neuroimaging has provided significant contributions revealing functional and structural alternations in the brains of drug addicts. However, the underlying neural mechanism in the OFC and its correlates with drug addiction and anxiety still require further elucidation. We first presented a pilot investigation to examine local networks in OFC regions through resting-state functional connectivity (rsFC) using functional near-infrared spectroscopy (fNIRS) from eight abstinent addicts in a heroin-dependent group (HD) and seven subjects in a control group (CG). We discovered that the HDs manifested enhanced interhemispheric correlation and rsFC. Moreover, small-worldness was explored in the brain networks. In addition to the altered rsFC in the OFC networks, our examinations demonstrated associations in the functional connectivity between the left inferior frontal gyrus and other OFC regions related to anxiety in the HDs. The study provides important preliminary evidence of the complex OFC networks in heroin addiction and suggests neural correlates of anxiety. It opens a window in application of fNIRS to predict psychiatric trajectories and may create new insights into neural adaptations resulting from chronic opiate intake.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.