Evidence map›Paper›PMID 28421673›Full record

ArticleCNS neuroscience & therapeutics2017

Endothelial ErbB4 deficit induces alterations in exploratory behavior and brain energy metabolism in mice.

Gang Wu, Xiu-Xiu Liu, Nan-Nan Lu, Qi-Bing Liu, Yun Tian, Wei-Feng Ye, Guo-Jun Jiang, Rong-Rong Tao, Feng Han, Ying-Mei Lu

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in CNS neuroscience & therapeutics, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.2field-weighted citation impact, top 52% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 7 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 1 country.

Gang WuInstitute of Pharmacology and Toxicology, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, China.
Xiu-Xiu LiuInstitute of Pharmacology and Toxicology, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, China.
Nan-Nan LuInstitute of Pharmacology and Toxicology, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, China.
Qi-Bing LiuSchool of Pharmacy, Hainan Medical College, Haikou, China.
Yun TianInstitute of Pharmacology and Toxicology, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, China.
Wei-Feng YeInstitute of Pharmacology and Toxicology, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, China.
Guo-Jun JiangDepartment of Pharmacy, Zhejiang Xiaoshan Hospital, Hangzhou, Zhejiang, China.
Rong-Rong TaoInstitute of Pharmacology and Toxicology, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, China.
Feng HanInstitute of Pharmacology and Toxicology, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, China.ORCID http://orcid.org/0000-0002-7800-9852
Ying-Mei LuSchool of Medicine, Zhejiang University City College, Hangzhou, Zhejiang, China.
Zhejiang University · CNHainan Medical College Hospital · CNZhejiang Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

aimsThe receptor tyrosine kinase ErbB4 is present throughout the primate brain and has a distinct functional profile. In this study, we investigate the potential role of endothelial ErbB4 receptor signaling in the brain.

resultsHere, we show that the endothelial cell-specific deletion of ErbB4 induces decreased exploratory behavior in adult mice. However, the water maze task for spatial memory and the memory reconsolidation test reveal no changes; additionally, we observe no impairment in CaMKII phosphorylation in Cdh5Cre;ErbB4

conclusionsTargeting ErbB4 or the modulation of endothelial ErbB4 signaling may represent a rational pharmacological approach to treat neurological disorders.

Indexed as

AnimalsAntigens, CDApoptosis Regulatory ProteinsAutophagy-Related Protein-1 HomologAvoidance LearningBrainCadherin 5CadherinsEndothelial CellsEnergy MetabolismExploratory BehaviorFluorodeoxyglucose F18Glucose Transporter Type 1Interleukin-1betaMaze LearningMemoryAntigens, CDApoptosis Regulatory ProteinsAutophagy-Related Protein-1 HomologCadherin 5CadherinsErbb4 protein, mouseFluorodeoxyglucose F18Glucose Transporter Type 1Interleukin-1betaNeuregulin-1Nrg1 protein, mousePhosphoric Monoester HydrolasesProteinsReceptor, ErbB-4Slc2a1 protein, mouseTIGAR protein, mouseUlk1 protein, mousebrain metabolismCaMKIIendothelialErbB4exploratory behavior

Identifiers

PMID28421673
PMCPMC6492688
OpenAlexW2606004388

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.