Evidence map›Paper›PMID 28421666›Full record

ArticleAging cell2017

Genetic interplay between human longevity and metabolic pathways - a large-scale eQTL study.

Robert Häsler, Geetha Venkatesh, Qihua Tan, Friederike Flachsbart, Anupam Sinha, Philip Rosenstiel, Wolfgang Lieb, Stefan Schreiber, Kaare Christensen, Lene Christiansen and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Aging cell, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

  1. Article
  2. Futurization of Aging: Subjective Beliefs and Effects.Behavioral sciences (Basel, Switzerland) · 2022
    Article
  3. Exome-Wide Association Study Identifies FN3KRP and PGP as New Candidate Longevity Genes.The journals of gerontology. Series A, Biological sciences and medical sciences · 2021
    Article
  4. Article
  5. Article
  6. The Danish Twin Registry: An Updated Overview.Twin research and human genetics : the official journal of the International Society for Twin Studies · 2019
    Article
  7. Genetic and epigenetic regulation of human aging and longevity.Biochimica et biophysica acta. Molecular basis of disease · 2019
    Review
  8. Review
  9. Analysis of Polymorphisms in 59 Potential Candidate Genes for Association With Human Longevity.The journals of gerontology. Series A, Biological sciences and medical sciences · 2018
    Article
  10. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Robert HäslerInstitute of Clinical Molecular Biology, Kiel University, 24105, Kiel, Germany.
Geetha VenkateshInstitute of Clinical Molecular Biology, Kiel University, 24105, Kiel, Germany.
Qihua TanThe Danish Twin Registry, Unit of Epidemiology, Biostatistics and Biodemography, University of Southern Denmark, 5000, Odense, Denmark.
Friederike FlachsbartInstitute of Clinical Molecular Biology, Kiel University, 24105, Kiel, Germany.
Anupam SinhaInstitute of Clinical Molecular Biology, Kiel University, 24105, Kiel, Germany.
Philip RosenstielInstitute of Clinical Molecular Biology, Kiel University, 24105, Kiel, Germany.
Wolfgang LiebInstitute of Epidemiology, Kiel University, 24105, Kiel, Germany.
Stefan SchreiberInstitute of Clinical Molecular Biology, Kiel University, 24105, Kiel, Germany.
Kaare ChristensenThe Danish Twin Registry, Unit of Epidemiology, Biostatistics and Biodemography, University of Southern Denmark, 5000, Odense, Denmark.
Lene ChristiansenThe Danish Twin Registry, Unit of Epidemiology, Biostatistics and Biodemography, University of Southern Denmark, 5000, Odense, Denmark.
Almut NebelInstitute of Clinical Molecular Biology, Kiel University, 24105, Kiel, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Human longevity is a complex phenotype influenced by genetic and environmental components. Unraveling the contribution of genetic vs. nongenetic factors to longevity is a challenging task. Here, we conducted a large-scale RNA-sequencing-based expression quantitative trait loci study (eQTL) with subsequent heritability analysis. The investigation was performed on blood samples from 244 individuals from Germany and Denmark, representing various age groups including long-lived subjects up to the age of 104 years. Our eQTL-based approach revealed for the first time that human longevity is associated with a depletion of metabolic pathways in a genotype-dependent and independent manner. Further analyses indicated that 20% of the differentially expressed genes are influenced by genetic variants in cis. The subsequent study of twins showed that the transcriptional activity of a third of the differentially regulated genes is heritable. These findings suggest that longevity-associated biological processes such as altered metabolism are, to a certain extent, also the driving force of longevity rather than just a consequence of old age.

Indexed as

Polymorphism, Single NucleotideQuantitative Trait LociTranscriptomeAdultAgedAged, 80 and overDenmarkGenome, HumanGenotypeGermanyHigh-Throughput Nucleotide SequencingHumansLongevityLongitudinal StudiesMetabolic Networks and PathwaysMiddle Agedfunctional genomicshumanlongevityRNA- sequencingtranscriptome

Identifiers

PMID28421666
PMCPMC5506416

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.