Evidence map›Paper›PMID 28421512›Full record

ReviewCurrent allergy and asthma reports2017

New Insights into Cockroach Allergens.

Anna Pomés, Geoffrey A Mueller, Thomas A Randall, Martin D Chapman, L Karla Arruda

Open access · greenAbstract readReview
In one paragraph

Review in Current allergy and asthma reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
44citing papers in PubMed, 1 pooled it
4.8field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

44 citing papers in PubMed, 1 synthesis or guideline pooled it, 98 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Article
  4. Article
  5. Review
  6. Review
  7. Disruption of model pulmonary surfactant membranes by the cockroach allergen Bla g 1.The journal of allergy and clinical immunology. Global · 2025
    Article
  8. Early-Life Allergen Exposure and Its Influence on Risk of Atopic Disease.The journal of allergy and clinical immunology. In practice · 2025
    Review
  9. Article
  10. Article
  11. Article
  12. Article
  13. Review
  14. Spatial distribution of histamine in bed bug-infested homes.The Science of the total environment · 2023
    Article
  15. Review
  16. Article
  17. Review
  18. Allergic rhinitis co-morbidity on asthma outcomes in city school children.The Journal of asthma : official journal of the Association for the Care of Asthma · 2023
    Article
  19. Cell reports methods · 2022
    Article
  20. In Silico Comparative Exploration of Allergens ofMolecules (Basel, Switzerland) · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 4 institutions in 2 countries.

Anna PomésIndoor Biotechnologies, Inc., 700 Harris Street, Charlottesville, VA, 22903, USA. apomes@inbio.com.
Geoffrey A MuellerGenome Integrity and Structural Biology Laboratory, Intramural Program, National Institute of Environmental Health Sciences, National Institutes of Health, 111 T.W. Alexander Drive, MD-MR01, Research Triangle Park, NC, 27709, USA.
Thomas A RandallIntegrative Bioinformatics, National Institute of Environmental Health Sciences, National Institutes of Health, 111 T.W. Alexander Drive, MD-MR01, Research Triangle Park, NC, 27709, USA.
Martin D ChapmanIndoor Biotechnologies, Inc., 700 Harris Street, Charlottesville, VA, 22903, USA.
L Karla ArrudaDepartment of Medicine, Ribeirao Preto Medical School, University of Sao Paulo, Av. Bandeirantes 3900, Ribeirao Preto, SP, 14049-900, Brazil.
Indoor Biotechnologies (United States) · USNational Institute of Environmental Health Sciences · USNational Institutes of Health · USUniversidade de São Paulo · BR

Funding

Structural and Functional Characterization of AllergensZIAES102906 · NIEHS · NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES · PI MUELLER, GEOFFREY · 2010 to 2025
$10.0M
Antigenic determinants of asthma-associated allergens for design of immunotherapy.R01AI077653 · NIAID · INDOOR BIOTECHNOLOGIES · PI MARTIN D. CHAPMAN, Maksymilian Chruszcz · 2009 to 2026
$9.5M
NIAID NIH HHS R01 AI077653
6 · The paper itself

Abstract

purpose of reviewThis review addresses the most recent developments on cockroach allergen research in relation to allergic diseases, especially asthma. RECENT

findingsThe number of allergens relevant to cockroach allergy has recently expanded considerably up to 12 groups. New X-ray crystal structures of allergens from groups 1, 2, and 5 revealed interesting features with implications for allergen standardization, sensitization, diagnosis, and therapy. Cockroach allergy is strongly associated with asthma particularly among children and young adults living in inner-city environments, posing challenges for disease control. Environmental interventions targeted at reducing cockroach allergen exposure have provided conflicting results. Immunotherapy may be a way to modify the natural history of cockroach allergy and decrease symptoms and asthma severity among sensitized and exposed individuals. The new information on cockroach allergens is important for the assessment of allergen markers of exposure and disease, and for the design of immunotherapy trials.

Indexed as

AllergensAnimalsAsthmaChildCockroachesEnvironmental ExposureHumansAllergensAllergen structureAllergy diagnosisAsthmaCockroach allergyIgERecombinant allergens

Identifiers

PMID28421512
PMCPMC5575827
OpenAlexW2607121647

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.