Evidence map›Paper›PMID 28421466›Full record

ReviewCurrent osteoporosis reports2017

Parathyroid Diseases and T Cells.

M Neale Weitzmann, Roberto Pacifici

Abstract readReview
In one paragraph

Review in Current osteoporosis reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed, 1 pooled it
0.8field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 1 synthesis or guideline pooled it, 22 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Review
  4. Article
  5. High Parathyroid Hormone Rather than Low Vitamin D Is Associated with Reduced Event-Free Survival in Childhood Cancer.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2024
    Article
  6. Article
  7. Article
  8. Article
  9. Review
  10. Review
  11. Review
  12. Article
  13. Review
  14. Bone and the Immune System.Toxicologic pathology · 2017
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 1 country.

M Neale WeitzmannAtlanta U.S. Department of Veterans Affairs Medical Center, Decatur, GA, 30033, USA. mweitzm@emory.edu.
Roberto PacificiDivision of Endocrinology and Metabolism and Lipids, Department of Medicine, Emory University School of Medicine, 101 Woodruff Circle, 1305 WMB, Atlanta, GA, 30322, USA.
Emory University · USUnited States Department of Veterans Affairs · US

Funding

Neuro HPA Project 1U54AG062334 · NIA · EMORY UNIVERSITY · PI Ighovwerha Ofotokun · 2018 to 2026
$12.2M
T CELLS AND PTH INDUCED BONE LOSSR01AR054625 · NIAMS · EMORY UNIVERSITY · PI PACIFICI, ROBERTO · 2007 to 2016
$3.3M
Accelerated Bone Loss in Aging HIV-infected IndividualsR01AR068157 · NIAMS · EMORY UNIVERSITY · PI OFOTOKUN, IGHOVWERHA, WEITZMANN, MERVYN NEALE · 2015 to 2019
$3.3M
Effect of HIV Infection and HAART on Bone HomeostasisR01AR059364 · NIAMS · EMORY UNIVERSITY · PI OFOTOKUN, IGHOVWERHA, WEITZMANN, MERVYN NEALE · 2009 to 2013
$3.2M
IL-4, a key regulator of bone turnover in HIV and ARTR01AR070091 · NIAMS · EMORY UNIVERSITY · PI OFOTOKUN, IGHOVWERHA, WEITZMANN, MERVYN NEALE · 2016 to 2020
$3.2M
Bone Loss and Immune Reconstitution in HIV/AIDSR01AG040013 · NIA · EMORY UNIVERSITY · PI OFOTOKUN, IGHOVWERHA, WEITZMANN, MERVYN NEALE · 2011 to 2015
$2.8M
Emory R38 Research Training ProgramR38AI140299 · NIAID · EMORY UNIVERSITY · PI OFOTOKUN, IGHOVWERHA, ROUPHAEL, NADINE GEORGES · 2018 to 2021
$1.4M
Th17 cells and Tregs determine the catabolic and anabolic effects of PTH in boneR01DK108842 · NIDDK · EMORY UNIVERSITY · PI PACIFICI, ROBERTO · 2016 to 2018
$1.2M
Biological Actions and Cellular Targeting of Nanoparticles for Medical ApplicatioR01AR056090 · NIAMS · EMORY UNIVERSITY · PI BECK, GEORGE R., WEITZMANN, MERVYN NEALE · 2008 to 2010
$984k
In Vivo MicroCT ScannerS10RR028009 · NCRR · EMORY UNIVERSITY · PI PACIFICI, ROBERTO · 2010 to 2010
$494k
Immune Regulation of Bone HomeostasisI01BX000105 · VA · VETERANS HEALTH ADMINISTRATION · PI WEITZMANN, MERVYN NEALE · 2009 to 2022
–
BLRD VA I01 BX000105NCRR NIH HHS S10 RR028009NIAID NIH HHS R38 AI140299NIAMS NIH HHS R01 AR054625NIAMS NIH HHS R01 AR056090NIAMS NIH HHS R01 AR059364NIAMS NIH HHS R01 AR068157NIAMS NIH HHS R01 AR070091NIA NIH HHS R01 AG040013NIA NIH HHS U54 AG062334NIDDK NIH HHS R01 DK108842
6 · The paper itself

Abstract

purpose of reviewThis review summarizes studies into the permissive role of T cells in the bone catabolic effects of hyperparathyroidism and parathyroid hormone (PTH). RECENT

findingsWork in animals combined with recent translational studies in humans now highlight the potent amplificatory action of T cells on PTH-induced bone resorption. Mechanistic animal studies reveal a complex pathway by which PTH exploits natural self-renewal functions of CD4

Indexed as

Bone ResorptionCD4-Positive T-LymphocytesHumansHyperparathyroidismInterleukin-17OsteoclastsOsteoprotegerinParathyroid DiseasesParathyroid HormoneRANK LigandTh17 CellsT-LymphocytesTumor Necrosis Factor-alphaInterleukin-17OsteoprotegerinParathyroid HormoneRANK LigandTumor Necrosis Factor-alphaHyperparathyroidismOsteoimmunologyOsteoporosisParathyroid hormonePTHT cells

Identifiers

PMID28421466
PMCPMC5598774
OpenAlexW2605492206

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.