Evidence map›Paper›PMID 28421447›Full record

ArticleDoklady. Biochemistry and biophysics2017

Inhibition of P-glycoprotein stimulates cell death under Hypoxia-mimicking conditions.

A S Vdovin, P V Maximchik, A V Kulikov, B D Zhivotovsky, V G Gogvadze

Abstract read
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In one paragraph

Article in Doklady. Biochemistry and biophysics, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.1field-weighted citation impact, top 56% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 2 countries.

A S VdovinM.V. Lomonosov Moscow State University, Moscow, Russia.
P V MaximchikM.V. Lomonosov Moscow State University, Moscow, Russia.
A V KulikovM.V. Lomonosov Moscow State University, Moscow, Russia.
B D ZhivotovskyM.V. Lomonosov Moscow State University, Moscow, Russia. boris.zhivotovsky@ki.se.
V G GogvadzeM.V. Lomonosov Moscow State University, Moscow, Russia.
Karolinska Institutet · SELomonosov Moscow State University · RUNational Medical Research Center of Cardiology · RU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The most common drug resistance mechanism in tumor cells is expression on their surface of the energy-dependent pump like P-glycoprotein (P-gp) that expels chemotherapeutic agents from the interior. An imitation of the hypoxic condition by the iron chelator deferoxamine caused Hypoxia-inducible factor 1-alpha (HIF-1α) stabilization and inhibition of doxorubicin-induced apoptosis in colon cancer НСТ116 cells. P-gp blocker verapamil suppressed doxorubicin accumulation leading to cell death induction. Considering these results, P-gp may be used as a potential target to stimulate chemotherapeutic drugs activity that will contribute to more efficient tumor cells elimination.

Indexed as

ApoptosisATP Binding Cassette Transporter, Subfamily B, Member 1Cell HypoxiaDeferoxamineDoxorubicinHCT116 CellsHumansHypoxia-Inducible Factor 1, alpha SubunitSiderophoresVerapamilATP Binding Cassette Transporter, Subfamily B, Member 1DeferoxamineDoxorubicinHIF1A protein, humanHypoxia-Inducible Factor 1, alpha SubunitSiderophoresVerapamil

Identifiers

PMID28421447
OpenAlexW2606878176

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.