Evidence map›Paper›PMID 28421398›Full record

ArticleInternational ophthalmology2018

Supradescemetic voriconazole injection for Candida parapsilosis keratitis.

Nikolaos Mamas, Konstantinos Andreanos, Klio Chatzistefanou, Petros Petrou, Dimitrios Brouzas, George Kymionis, Chrysanthi Koutsandrea, Konstantinos Droutsas

Abstract readCase Reports
PubMed Publisher
In one paragraph

Article in International ophthalmology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.7field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 5 citations in OpenAlex.

  1. Post-corneal transplantIndian journal of ophthalmology · 2022
    Article
  2. First case ofMedical mycology case reports · 2021
    Article
  3. [Candida parapsilosis infection in a corneal transplant patient].Revista espanola de quimioterapia : publicacion oficial de la Sociedad Espanola de Quimioterapia · 2018
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 2 countries.

Nikolaos MamasFirst Department of Ophthalmology, National and Kapodistrian University of Athens, Mesogeion Ave 154, 156 67, Athens, Greece. nikolaos.mamas@gmail.com.
Konstantinos AndreanosFirst Department of Ophthalmology, National and Kapodistrian University of Athens, Mesogeion Ave 154, 156 67, Athens, Greece.
Klio ChatzistefanouFirst Department of Ophthalmology, National and Kapodistrian University of Athens, Mesogeion Ave 154, 156 67, Athens, Greece.
Petros PetrouFirst Department of Ophthalmology, National and Kapodistrian University of Athens, Mesogeion Ave 154, 156 67, Athens, Greece.
Dimitrios BrouzasFirst Department of Ophthalmology, National and Kapodistrian University of Athens, Mesogeion Ave 154, 156 67, Athens, Greece.
George KymionisFirst Department of Ophthalmology, National and Kapodistrian University of Athens, Mesogeion Ave 154, 156 67, Athens, Greece.
Chrysanthi KoutsandreaFirst Department of Ophthalmology, National and Kapodistrian University of Athens, Mesogeion Ave 154, 156 67, Athens, Greece.
Konstantinos DroutsasFirst Department of Ophthalmology, National and Kapodistrian University of Athens, Mesogeion Ave 154, 156 67, Athens, Greece.
National and Kapodistrian University of Athens · GR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeTo describe a technique for intracorneal application of voriconazole into the supradescemetic space in a case of deep recalcitrant Candida parapsilosis keratitis of a penetrating cornea graft.

methodsA deep intracorneal incision reaching the center of the corneal infiltrate was created with a 20-gauge MVR blade. Then, a 27-gauge hydrodissection cannula was inserted deep into the corneal pocket, and 0.1 ml of voriconazole 0.5 mg/ml was injected until a bullous detachment of Descemet membrane (DM) covered 1/3 of the graft's area. DM detachment was documented by anterior segment optical coherence tomography (AS-OCT).

resultsAS-OCT confirmed the creation of a drug depot in the supradescemetic space, which partially regressed during the following hours; 24 h after the injection, a complete reattachment of DM was documented. After 4 weeks, the stromal infiltrate has cleared completely and no signs of recurrence were observed 3 months after injection.

conclusionIn the present case, the supradescemetic voriconazole injection led to resolution of a deep recalcitrant fungal infiltrate. The herein described technique could be tried in similar cases, where an intrastromal injection is indicated, as it may offer a larger intracorneal drug depot.

Indexed as

Aged, 80 and overAntifungal AgentsCandida parapsilosisEye Infections, FungalHumansInjections, IntraocularKeratitisMaleTreatment OutcomeVoriconazoleAntifungal AgentsVoriconazoleCandida parapsilosisIntracorneal injectionKeratitisSupradescemetic injectionVoriconazole

Identifiers

PMID28421398
OpenAlexW2607376788

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.