ArticleBiogerontology2017
Association of adiponectin, leptin and resistin with inflammatory markers and obesity in dementia.
Article in Biogerontology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
45 citing papers in PubMed, 2 syntheses or guidelines pooled it, 80 citations in OpenAlex.
- Prevalence of metabolic syndrome among patients with Alzheimer disease: A systematic review and meta-analysis.Medicine · 2026Pooled it
- The role of adiponectin in Alzheimer's disease: A translational review.The journal of nutrition, health & aging · 2024Pooled it
- Association Between Insulin Resistance, Plasma Leptin, and Neurocognition in Vascular Cognitive Impairment.Journal of Alzheimer's disease : JAD · 2019Trial
- Associations of circulating resistin with Alzheimer's disease biomarkers and cognitive function in the preclinical stage of Alzheimer's disease.Journal of Alzheimer's disease : JAD · 2026Article
- Obesity-induced cognitive impairment: Underlying mechanisms and therapeutic prospects.Metabolism open · 2026Review
- Leptin as a Potential Modifier of Neuroinflammation: Contrasting Roles in Alzheimer's Disease and Multiple Sclerosis.International journal of molecular sciences · 2025Review
- Integrative multi-omics approaches identify molecular pathways and improve Alzheimer's disease risk prediction.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Article
- Association of resistin rs1862513, rs10401670 and rs3745367 polymorphisms with resistin level and insulin resistance in an Iranian type 2 diabetic population.Journal of diabetes and metabolic disorders · 2025Article
- Higher serum resistin levels and increased frailty risk in older adults: Implications beyond metabolic function.The journal of nutrition, health & aging · 2025Article
- Neuro-Adipokine Crosstalk in Alzheimer's Disease.International journal of molecular sciences · 2024Review
- The Causal Associations between Adipokines and Alzheimer's Disease: A Two-Sample Mendelian Randomization Study.Journal of Alzheimer's disease reports · 2024Article
- Review
- Inflammation-Involved Proteins in Blood Serum of Cataract Patients-A Preliminary Study.Biomedicines · 2023Article
- Exploring the effects of adiponectin and leptin in correlating obesity with cognitive decline: a systematic review.Annals of medicine and surgery (2012) · 2023Article
- Evaluation of Selected Parameters of Oxidative Stress and Adipokine Levels in Hospitalized Older Patients with Diverse Nutritional Status.Antioxidants (Basel, Switzerland) · 2023Article
- Decreased resistin plasmatic concentrations in patients with Alzheimer's disease: A case-control study.Heliyon · 2022Article
- Adiponectin, Leptin, and Resistin and the Risk of Dementia.The journals of gerontology. Series A, Biological sciences and medical sciences · 2022Article
- Association between inflammatory markers and serum paraoxonase and arylesterase activities in the general population: a cross-sectional study.Lipids in health and disease · 2021Article
- Carnosic acid alleviates depression-like behaviors on chronic mild stressed mice via PPAR-γ-dependent regulation of ADPN/FGF9 pathway.Psychopharmacology · 2021Article
- Resistin is a risk factor for all-cause mortality in elderly Finnish population: A prospective study in the OPERA cohort.PloS one · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The aim of the study was to determine the role of adiponectin, leptin and resistin in various types of dementia and to investigate their association with inflammatory markers, insulin resistance and abdominal obesity. In 205 patients with dementia [89 with Alzheimer's disease (AD), 47 with vascular dementia (VaD), 69 with mixed dementia (MD)], 113 persons with mild cognitive impairment and in 107 controls serum adiponectin, leptin and resistin levels, pro-inflammatory [interleukin-6 (IL-6), C-reactive protein (hsCRP) and chitotriosidase] and anti-inflammatory (25-OH vitamin D, HDL-cholesterol and paraoxonase 1) markers, as well as glucose metabolism parameters (glucose, insulin and HOMA-IR) were determined. In all-cause dementia adiponectin and resistin levels were significantly higher as compared to the controls; leptin levels did not show differences. Higher adiponectin levels concerned AD and MD, whereas higher resistin-VaD and MD. After stratification by abdominal obesity the differences in adiponectin levels remained significant in subjects without obesity. In all-cause dementia negative correlation of adiponectin with obesity, glucose metabolism parameters, IL-6 and hsCRP and positive correlation with HDL-cholesterol were found. Positive correlation of resistin with age, IL-6, hsCRP and chitotriosidase and negative correlation with HDL-cholesterol and paraoxonase 1 were stated. We conclude that dementia of neurodegenerative origin is characterized by elevated adiponectin levels, whereas dementia with vascular changes by increase of resistin. Association with inflammatory indicators may suggest the pro-inflammatory role of resistin in the development of dementia, especially in dementia of vascular mechanism. Identification of this novel biomarker may be important in preventing dementia.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.