Trial reportClinical and experimental nephrology2018
Compared effects of calcium and sodium polystyrene sulfonate on mineral and bone metabolism and volume overload in pre-dialysis patients with hyperkalemia.
Trial report in Clinical and experimental nephrology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed, 2 syntheses or guidelines pooled it, 29 citations in OpenAlex.
- Binding Potassium to Improve Treatment With Renin-Angiotensin-Aldosterone System Inhibitors: Results From Multiple One-Stage Pairwise and Network Meta-Analyses of Clinical Trials.Frontiers in medicine · 2021Pooled it
- Potassium binders for chronic hyperkalaemia in people with chronic kidney disease.The Cochrane database of systematic reviews · 2020Pooled it
- Management of hyperkalemia: strategic clinical actions in real-world practice.Clinical and experimental nephrology · 2025Review
- Sodium Polystyrene Sulfonate and Heart Failure Risk: A Comparative Study With Calcium Polystyrene Sulfonate.Nephrology (Carlton, Vic.) · 2025Article
- Sodium intake and urinary losses in children on dialysis: a European multicenter prospective study.Pediatric nephrology (Berlin, Germany) · 2023Article
- In vitro and in vivo removal efficacy of insoluble Prussian blue in combination with calcium polystyrene sulfonate for thallium.Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine · 2023Article
- Hyperkalemia: Prevalence, Predictors and Emerging Treatments.Cardiology and therapy · 2023Review
- Compared effectiveness of sodium zirconium cyclosilicate and calcium polystyrene sulfonate on hyperkalemia in patients with chronic kidney disease.Frontiers in medicine · 2023Article
- Prescription Pattern of Cation Exchange Resins and Their Efficacy in Treating Chronic Hyperkalemia Among Patients With Chronic Kidney Diseases: Findings From a Population-Based Analysis in British Columbia, Canada.Canadian journal of kidney health and disease · 2022Article
- Hyperkalemia management in the emergency department: An expert panel consensus.Journal of the American College of Emergency Physicians open · 2021Article
- The associations between serum trace elements and bone mineral density in children under 3 years of age.Scientific reports · 2021Article
- Management of Chronic Hyperkalemia in Patients With Chronic Kidney Disease: An Old Problem With News Options.Frontiers in medicine · 2021Review
- Polysulfonate Resins in Hyperkalemia: A Systematic Review.Canadian journal of kidney health and disease · 2020Article
- Article
- Pharmacologic Treatment of Chronic Hyperkalemia in Patients with Chronic Kidney Disease.Electrolyte & blood pressure : E & BP · 2019Review
- Assessment and management of fluid overload in children on dialysis.Pediatric nephrology (Berlin, Germany) · 2019Review
- Efficacy and safety of the pharmacotherapy used in the management of hyperkalemia: a systematic review.Pharmacy practiceArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
17 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundHyperkalemia is prevalent in end-stage renal disease patients, being involved in life-threatening arrhythmias. Although polystyrene sulfonate (PS) is commonly used for the treatment of hyperkalemia, direct comparison of effects between calcium and sodium PS (CPS and SPS) on mineral and bone metabolism has not yet been studied.
methodsIn a randomized and crossover design, 20 pre-dialysis patients with hyperkalemia (>5 mmol/l) received either oral CPS or SPS therapy for 4 weeks.
resultsAfter 4-week treatments, there was no significant difference of changes in serum potassium (K) from the baseline (ΔK) between the two groups. However, SPS significantly decreased serum calcium (Ca) and magnesium (Mg) and increased intact parathyroid hormone (iPTH) values, whereas CPS reduced iPTH. ΔiPTH was inversely correlated with ΔCa and ΔMg (r = -0.53 and r = -0.50, respectively). Furthermore, sodium (Na) and atrial natriuretic peptide (ANP) levels were significantly elevated in patients with SPS, but not with CPS, whereas ΔNa and ΔANP were significantly correlated with each other in all the patients. We also found that ΔNa and Δ(Na to chloride ratio) were positively correlated with ΔHCO
conclusionCompared with SPS, CPS may be safer for the treatment of hyperkalemia in pre-dialysis patients, because it did not induce hyperparathyroidism or volume overload.
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