ArticleEuropean journal of nutrition2018
Associations between a Mediterranean diet pattern and inflammatory biomarkers in European adolescents.
Article in European journal of nutrition, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers, 2 of them syntheses that pooled it.
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Who cites it
33 citing papers in PubMed, 2 syntheses or guidelines pooled it, 53 citations in OpenAlex.
- Associations of Dietary Intake on Biological Markers of Inflammation in Children and Adolescents: A Systematic Review.Nutrients · 2021Pooled it
- The Effect of Nut Consumption on Diet Quality, Cardiometabolic and Gastrointestinal Health in Children: A Systematic Review of Randomized Controlled Trials.International journal of environmental research and public health · 2021Pooled it
- Serum TLR4, NF-κB, and NLRP3 Levels in Children with Attention-Deficit/Hyperactivity Disorder: A Case-Control Study.Children (Basel, Switzerland) · 2026Article
- MELI-POP Study: MEditerranean LIfestyle in Pediatric Obesity Prevention. Study protocol for a randomized controlled trial.BMC public health · 2025Article
- Can Diet Quality Be Associated with Disease Activity in a Prospective Dutch Inflammatory Bowel Disease Cohort?Nutrients · 2025Article
- The role of nutrition and gut microbiome in childhood brain development and behavior.Frontiers in nutrition · 2025Review
- Diet-related behaviors affecting health and substance use among children and adolescents.Clinical and experimental pediatrics · 2024Article
- The relationship between periodontal status, physical activity, dietary practices, and dental caries.Scientific reports · 2024Article
- The association between dairy intake in adolescents on inflammation and risk markers of type 2 diabetes during young adulthood: results of the DONALD study.Public health nutrition · 2024Article
- Dietary habits, depression and obesity: an intricate relationship to explore in pediatric preventive strategies.Frontiers in pediatrics · 2024Review
- Association between HMGCR, CRP, and CETP gene polymorphisms and metabolic/inflammatory serum profile in healthy adolescents.Journal of translational medicine · 2023Article
- Article
- Review
- Low-Grade Inflammation and Role of Anti-Inflammatory Diet in Childhood Obesity.International journal of environmental research and public health · 2023Review
- The Mediterranean Diet and the Western Diet in Adolescent Depression-Current Reports.Nutrients · 2022Review
- Adherence to Mediterranean diet, physical activity level, and severity of periodontitis: Results from a university-based cross-sectional study.Journal of periodontology · 2022Article
- Micronutrient deficiencies and cardiac health.Frontiers in nutrition · 2022Article
- Can dietary intake protect against low-grade inflammation in children and adolescents?Brain, behavior, & immunity - health · 2021Review
- Dietary inflammatory index scores are associated with atherogenic risk in Brazilian schoolchildren.Public health nutrition · 2021Article
- Nutrition Education Program and Physical Activity Improve the Adherence to the Mediterranean Diet: Impact on Inflammatory Biomarker Levels in Healthy Adolescents From the DIMENU Longitudinal Study.Frontiers in nutrition · 2021Article
Corrections and comments
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Authors and funding
19 authors at 14 institutions in 9 countries.
Funding
Abstract
aimTo test whether the Mediterranean diet score and each food-subgroup is associated with inflammatory biomarkers in European adolescents.
methodsIn 464 adolescents (13-17 years) of the European HELENA study, data were available on body composition, inflammation markers, and food intake determined by two computerized 24-h recalls. The Mediterranean diet score and its food-subgroups (Vegetables, Fruits and Nuts, Pulses, Cereal and Roots, Monounsaturated/Saturated fat ratio, Dairy, Fish, Meat and Alcohol) were evaluated. A set of inflammation-related biomarkers was measured: IL-1, IL-2, IL-4, IL-5, IL-6, IL-10, TGFβ-1, TNF-α, sVCAM-1, sICAM1, sE-selectin, white blood cells, lymphocytes, CD3, CRP, GGT, ALT, and homocysteine. Multivariate and multiple linear regression analyses were adjusted for age, sex, country, socioeconomic status, paternal and maternal education, adiposity, and smoking habits.
resultsThe Mediterranean diet score was positively associated with CRP, and negatively with sVCAM-1. The subgroups showed the following positive/negative associations: Vegetables with IL-10(+), CRP(+), CD3(+), ALT(+), lymphocytes(+), sE-selectin(-); Fruits and Nuts with IL-4(-), TNF-alpha; Pulses with IL-5(+), IL-6(+), IL-2(-); Cereals and Roots with IL-6(-), IL-10(-); Monounsaturated/Saturated-fat ratio with IL-6(+), TGFβ-1(+), sVCAM-1(+boys, -girls), homocysteine(-); Dairy with IL-1(+), IL-5(+), IL-6(+), IL-10(+), TGFβ-1(+), homocysteine(-); Fish with homocysteine(-); Meat with IL-2(+), IL-10(+); Alcohol with CRP(+), lymphocytes(-). Sex differences were found.
conclusionSome specific food-inflammation associations were found, suggesting that diet is to a certain extent already related to inflammation in adolescents and can be used in disease prevention. Also some counterintuitive results were found, which might be due to grouping very different foods into a single group, besides considering that the human body may respond differently depending on the interaction between diet, lifestyle, genetics, biochemical individuality, age and sex.
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Registered trials
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