Evidence map›Paper›PMID 28421181›Full record

ArticleFrontiers in cell and developmental biology2017

MCT1 in Invasive Ductal Carcinoma: Monocarboxylate Metabolism and Aggressive Breast Cancer.

Jennifer M Johnson, Paolo Cotzia, Roberto Fratamico, Lekha Mikkilineni, Jason Chen, Daniele Colombo, Mehri Mollaee, Diana Whitaker-Menezes, Marina Domingo-Vidal, Zhao Lin and 5 more

Open access · goldAbstract read
In one paragraph

Article in Frontiers in cell and developmental biology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 52 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
52citing papers in PubMed, 1 pooled it
2.2field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

52 citing papers in PubMed, 1 synthesis or guideline pooled it, 67 citations in OpenAlex.

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  10. International journal of molecular sciences · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 6 institutions in 2 countries.

Jennifer M JohnsonDepartment of Medical Oncology, Sidney Kimmel Cancer Center, Thomas Jefferson UniversityPhiladelphia, PA, USA.
Paolo CotziaDepartment of Pathology, Memorial Sloan Kettering Cancer CenterNew York, NY, USA.
Roberto FratamicoDepartment of Medical Oncology, Sidney Kimmel Cancer Center, Thomas Jefferson UniversityPhiladelphia, PA, USA.
Lekha MikkilineniMedical Oncology, National Cancer InstituteBethesda, MD, USA.
Jason ChenDepartment of Medical Oncology, Sidney Kimmel Cancer Center, Thomas Jefferson UniversityPhiladelphia, PA, USA.
Daniele ColomboPathology, University of Rome Tor VergataRome, Italy.
Mehri MollaeeDepartment of Pathology, Anatomy and Cell Biology, Thomas Jefferson UniversityPhiladelphia, PA, USA.
Diana Whitaker-MenezesDepartment of Medical Oncology, Sidney Kimmel Cancer Center, Thomas Jefferson UniversityPhiladelphia, PA, USA.
Marina Domingo-VidalDepartment of Medical Oncology, Sidney Kimmel Cancer Center, Thomas Jefferson UniversityPhiladelphia, PA, USA.
Zhao LinDepartment of Medical Oncology, Sidney Kimmel Cancer Center, Thomas Jefferson UniversityPhiladelphia, PA, USA.
Tingting ZhanDivision of Biostatistics, Department of Pharmacology and Experimental Therapeutics, Thomas Jefferson UniversityPhiladelphia, PA, USA.
Madalina TulucDepartment of Pathology, Anatomy and Cell Biology, Thomas Jefferson UniversityPhiladelphia, PA, USA.
Juan PalazzoDepartment of Pathology, Anatomy and Cell Biology, Thomas Jefferson UniversityPhiladelphia, PA, USA.
Ruth C BirbeDepartment of Pathology, Cooper University HospitalCamden, NJ, USA.
Ubaldo E Martinez-OutschoornDepartment of Medical Oncology, Sidney Kimmel Cancer Center, Thomas Jefferson UniversityPhiladelphia, PA, USA.
Thomas Jefferson University · USSidney Kimmel Cancer Center · USCooper University Hospital · USMemorial Sloan Kettering Cancer Center · USNational Cancer Institute · USUniversity of Rome Tor Vergata · IT

Funding

Metabolic mechanisms of antiestrogen resistance in breast cancerK08CA175193 · NCI · THOMAS JEFFERSON UNIVERSITY · PI MARTINEZ OUTSCHOORN, UBALDO · 2013 to 2017
$831k
NCI NIH HHS K08 CA175193
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

glycolysislactic acidoxidative phosphorylationtriple negative breast cancertumor microenvironment

Identifiers

PMID28421181
PMCPMC5376582
OpenAlexW2602922057

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.