Evidence map›Paper›PMID 28421032›Full record

ReviewFrontiers in neurology2017

Spasticity, Motor Recovery, and Neural Plasticity after Stroke.

Sheng Li

3 registry-linked trialsOpen access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Frontiers in neurology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 3 registered trials, which are not on this map. Cited by 153 papers, 13 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
153citing papers in PubMed, 13 pooled it
17.6field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04379687 naunknown statusnot on this mapstarted 2020, after this paper: background citation

Immersive Virtual Reality in Post Stroke Physiotherapy

TypeinterventionalSponsorYolanda Marcen RomanRan2020 to 2023Enrolled44ConditionsBalance, Stroke, Physical Therapy, Virtual RealityArmsVirtual reality, Control group
NCT07156760 completednot on this mapstarted 2025, after this paper: background citation

Morphological Characteristics of Spastic Musculature in the Upper and Lower Extremities Using Ultrasound Examination in Subjects After Stroke

Typeobservational_patient_registrySponsorUniversidad de La FronteraRan2025 to 2025Enrolled80ConditionsStrokeArmsUltrasound diagnostics
NCT07266662 narecruitingnot on this mapstarted 2025, after this paper: background citation

Comparative Effects of Sensory Augmentation and Neuromodulation on Enhancing Motor Recovery Among Stroke Survivors

TypeinterventionalSponsorLahore University of Biological and Applied SciencesRan2025 to 2026Enrolled36ConditionsStroke (CVA) or Transient Ischemic AttackArmsSensory Augmentation, Neuromodulation, Combination of Sensory Augmentation and Neuromodulation
3 · Its place in the literature

Who cites it

153 citing papers in PubMed, 13 syntheses or guidelines pooled it, 313 citations in OpenAlex.

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  9. The role of virtual reality on outcomes in rehabilitation of Parkinson's disease: meta-analysis and systematic review in 1031 participants.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2020
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93 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author at 1 institution in 1 country.

Sheng LiDepartment of Physical Medicine and Rehabilitation, University of Texas Health Science Center, Houston, TX, USA.
The University of Texas Health Science Center at Houston · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Spasticity and weakness (spastic paresis) are the primary motor impairments after stroke and impose significant challenges for treatment and patient care. Spasticity emerges and disappears in the course of complete motor recovery. Spasticity and motor recovery are both related to neural plasticity after stroke. However, the relation between the two remains poorly understood among clinicians and researchers. Recovery of strength and motor function is mainly attributed to cortical plastic reorganization in the early recovery phase, while reticulospinal (RS) hyperexcitability as a result of maladaptive plasticity, is the most plausible mechanism for poststroke spasticity. It is important to differentiate and understand that motor recovery and spasticity have different underlying mechanisms. Facilitation and modulation of neural plasticity through rehabilitative strategies, such as early interventions with repetitive goal-oriented intensive therapy, appropriate non-invasive brain stimulation, and pharmacological agents, are the keys to promote motor recovery. Individualized rehabilitation protocols could be developed to utilize or avoid the maladaptive plasticity, such as RS hyperexcitability, in the course of motor recovery. Aggressive and appropriate spasticity management with botulinum toxin therapy is an example of how to create a transient plastic state of the neuromotor system that allows motor re-learning and recovery in chronic stages.

Indexed as

motor recoveryneuroplasticityrehabilitationspasticitystroke

Identifiers

PMID28421032
PMCPMC5377239
OpenAlexW2604940191

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.